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Aphelion Capital

North America, Colorado, United States, Littleton

Description

Aphelion Capital is a specialized venture capital firm based in Littleton, Colorado, dedicated to fostering innovation within the medical technology and digital health sectors. Established with a clear vision, the firm focuses on identifying and supporting early-stage companies that are developing groundbreaking solutions to address critical healthcare needs. Their investment thesis centers on technologies that promise to significantly improve patient outcomes, enhance healthcare efficiency, and disrupt traditional medical paradigms.

The firm primarily targets Seed and Series A funding rounds, often taking a lead or co-lead position in these investments. Aphelion Capital's strategic approach involves not just providing capital, but also actively engaging with portfolio companies to guide their growth and development. According to their official statements, initial investments typically range from $1 million to $5 million, reflecting their commitment to providing substantial early-stage capital to promising ventures. They also participate in follow-on rounds, including Series B, to continue supporting their portfolio as companies scale.

Since its inception in 2004, Aphelion Capital has built a focused portfolio of companies at the forefront of medical innovation. Their investment activity demonstrates a consistent commitment to the healthcare sector, with Crunchbase indicating they have made at least 14 investments to date. This long-standing presence and specialized focus allow them to leverage deep industry expertise and networks to benefit their portfolio companies. Aphelion Capital's strategy emphasizes the creation and growth of companies that are poised to make a significant impact on the future of healthcare.

Investor Profile

Aphelion Capital has backed more than 37 startups, with 3 new investments in the last 12 months alone. The firm has led 8 rounds, about 22% of its total and boasts 9 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series C, Series A, Series B rounds (top funding stages).
  • Majority of deals are located in United States, United Kingdom, Canada.
  • Strong thematic focus on Health Care, Medical Device, Medical.
  • Typical check size: $1M – $5M.

Stage Focus

  • Series C (27%)
  • Series A (24%)
  • Series B (19%)
  • Series D (14%)
  • Series Unknown (5%)
  • Seed (5%)
  • Debt Financing (3%)
  • Series E (3%)

Country Focus

  • United States (95%)
  • United Kingdom (3%)
  • Canada (3%)

Industry Focus

  • Health Care
  • Medical Device
  • Medical
  • Biotechnology
  • Wearables
  • Software
  • Clinical Trials
  • Hospital
  • Manufacturing
  • Health Diagnostics
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does Aphelion Capital frequently co-invest with?

Ameritas Life Insurance
North America, Nebraska, United States, Lincoln
Co-Investments: 3
Features Capital
North America, Vermont, United States, Norwich
Co-Investments: 4
Hikma Ventures
Europe, England, United Kingdom, London
Co-Investments: 3
RiverVest
North America, Missouri, United States, St Louis
Co-Investments: 3
Research Corporation Technologies
North America, Arizona, United States, Tucson
Co-Investments: 3
Medvest Capital
North America, Florida, United States, Palm Beach Gardens
Co-Investments: 3
RC Capital
North America, Ohio, United States, Cincinnati
Co-Investments: 4
Taisho Pharmaceutical Holdings
Asia, Tokyo, Japan, Tokyo
Co-Investments: 3
M Ventures
Europe, Noord-Holland, The Netherlands, Amsterdam
Co-Investments: 3
California Technology Ventures
North America, California, United States, Pasadena
Co-Investments: 6

What are some of recent deals done by Aphelion Capital?

Biolinq

San Diego, California, United States

Biolinq develops a wearable biosensor platform that is capable of measuring blood level information.

BiotechnologyHealth CareMedical DeviceWearables
Series CApr 22, 2025
Amount Raised: $100,000,000
Laplace Interventional

Plymouth, Minnesota, United States

Laplace is a medical device company that develops transcatheter tricuspid valve technology.

Health CareMedicalMedical Device
Series CMar 16, 2025
Amount Raised: $22,000,000
Venova Medical

Los Gatos, California, United States

Venova Medical develops vascular access systems for patients requiring renal replacement therapy.

Health CareMedicalMedical DeviceTherapeutics
Series BSep 4, 2024
Amount Raised: $30,000,000
Nectero Medical

Tempe, Arizona, United States

Nectero Medical develops a novel treatment to stabilize growth and prevent rupture of mid-sized abdominal aortic aneurysms.

BiotechnologyHealth CareHealth DiagnosticsMedical Device
Series DApr 11, 2024
Amount Raised: $96,000,000
Biolinq

San Diego, California, United States

Biolinq develops a wearable biosensor platform that is capable of measuring blood level information.

BiotechnologyHealth CareMedical DeviceWearables
Series DApr 4, 2024
Amount Raised: $58,000,000
Phagenesis

Manchester, Manchester, United Kingdom

Phagenesis is engaged in the development of a device to treat dysphagia, a condition that disables the safe swallowing of food.

BiotechnologyHealth CareMedical
Series DMar 4, 2024
Amount Raised: $42,000,000
Moving Analytics

Los Angeles, California, United States

Moving Analytics is a telehealth service provider that specializes in cardiovascular prevention programs.

Health CareInformation TechnologyMedicalmHealthTelehealth
Series AJul 8, 2022
Amount Raised: $20,000,000
Elucid

Boston, Massachusetts, United States

Elucid enables precision medicine for cardiovascular disease by applying A.I to medical image analysis validated against true biology.

AnalyticsBiotechnologyMedical DevicePrecision Medicine
Series BJun 22, 2022
Amount Raised: $27,000,000
Biolinq

San Diego, California, United States

Biolinq develops a wearable biosensor platform that is capable of measuring blood level information.

BiotechnologyHealth CareMedical DeviceWearables
Series BNov 2, 2021
Amount Raised: $100,000,000
Moving Analytics

Los Angeles, California, United States

Moving Analytics is a telehealth service provider that specializes in cardiovascular prevention programs.

Health CareInformation TechnologyMedicalmHealthTelehealth
SeedApr 19, 2021
Amount Raised: $6,000,000