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Arboretum Ventures

North America, Michigan, United States, Ann Arbor

Description

Arboretum Ventures, established in 2002 and headquartered in Ann Arbor, Michigan, is a dedicated venture capital firm with a singular focus on the healthcare sector. The firm primarily targets companies developing innovative medical technologies and healthcare services, encompassing areas such as medical devices, diagnostics, healthcare information technology, and tech-enabled services. Their investment philosophy centers on identifying promising early-stage and growth-stage companies that are poised to disrupt or significantly improve the healthcare landscape.

As an active investor, Arboretum Ventures typically takes a hands-on approach, often securing a board seat and collaborating closely with management teams to foster growth and strategic development. The firm has demonstrated significant financial capacity, having successfully raised over $700 million across five distinct funds since its inception. Their most recent fund, Fund V, closed in 2019 with $220 million, underscoring their continued commitment and substantial capital available for new investments.

Arboretum Ventures' typical initial investment ranges from $5 million to $15 million, reflecting their commitment to providing substantial early capital to promising ventures. While their initial checks fall within this range, they possess the capacity to invest up to $25 million over the life of a company, supporting portfolio companies through various growth stages. Their robust portfolio includes more than 60 investments, with a track record of over 15 successful exits, highlighting their ability to identify and nurture companies towards significant liquidity events within the competitive healthcare market.

Investor Profile

Arboretum Ventures has backed more than 106 startups, with 5 new investments in the last 12 months alone. The firm has led 46 rounds, about 43% of its total and boasts 24 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series A, Series B, Series C rounds (top funding stages).
  • Majority of deals are located in United States, Canada.
  • Strong thematic focus on Health Care, Biotechnology, Medical Device.
  • Led 2 rounds in the past year.
  • Typical check size: $5M – $15M.

Stage Focus

  • Series A (25%)
  • Series B (25%)
  • Series C (17%)
  • Series Unknown (14%)
  • Series D (10%)
  • Series E (2%)
  • Seed (2%)
  • Series F (1%)
  • Private Equity (1%)
  • Series G (1%)

Country Focus

  • United States (98%)
  • Canada (2%)

Industry Focus

  • Health Care
  • Biotechnology
  • Medical Device
  • Medical
  • Pharmaceutical
  • Software
  • Health Diagnostics
  • Manufacturing
  • Hospital
  • Therapeutics
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does Arboretum Ventures frequently co-invest with?

Baird Capital
North America, Wisconsin, United States, Milwaukee
Co-Investments: 11
ONSET Ventures
North America, California, United States, Menlo Park
Co-Investments: 6
Chrysalis Ventures
North America, Kentucky, United States, Louisville
Co-Investments: 8
5AM Ventures
North America, California, United States, Menlo Park
Co-Investments: 7
Versant Ventures
North America, California, United States, Menlo Park
Co-Investments: 6
Beringea
North America, Michigan, United States, Farmington Hills
Co-Investments: 6
Lumira Ventures
North America, Ontario, Canada, Toronto
Co-Investments: 6
Venture Investors
North America, Wisconsin, United States, Madison
Co-Investments: 6
Aperture Venture Partners
North America, New York, United States, New York
Co-Investments: 6
Jazz Venture Partners
North America, California, United States, San Francisco
Co-Investments: 6

Which angels does Arboretum Ventures often collaborate with?

JR
North America, California, United States, San Francisco
Shared Deals: 1
SR
North America, California, United States, Palo Alto
Shared Deals: 1
SK
North America, California, United States, San Francisco
Shared Deals: 1
MH
North America, California, United States, San Francisco
Shared Deals: 1
RS
North America, Washington, United States, Seattle
Shared Deals: 2

What are some of recent deals done by Arboretum Ventures?

Allay Therapeutics

San Jose, California, United States

Allay Therapeutics offers analgesic products for post-surgical pain management and recuperation.

BiotechnologyHealth CareMedicalTherapeutics
Series DJun 5, 2025
Amount Raised: $57,500,000
Akadeum Life Sciences

Ann Arbor, Michigan, United States

Akadeum develops bioseparation products to facilitate the removal of target cells from biological samples.

BiotechnologyInformation TechnologyLife ScienceMedical
Series UnknownJun 3, 2025
Amount Raised: $20,000,000
Shoulder Innovations

Holland, Michigan, United States

Shoulder Innovations is a medical device company that develops inset glenoid fixation technology.

BiotechnologyHealth CareMedical Device
Series EMar 10, 2025
Amount Raised: $40,000,000
Francis Medical

Maple Grove, Minnesota, United States

Francis Medical is a medical technology company developing therapeutic solutions to treat prostate, kidney, and bladder cancer.

Medical
Series CJan 7, 2025
Amount Raised: $80,000,000
Orasis Pharmaceuticals

Ponte Vedra, Florida, United States

Orasis Pharmaceuticals is an ophthalmic pharmaceutical company that develops eye drops for the treatment of presbyopia.

Clinical TrialsHealth CareMedicalPharmaceutical
Series DOct 8, 2024
Amount Raised: $68,000,000
RareCyte

Seattle, Washington, United States

RareCyte is a life science research and diagnostic development company focused on characterizing and isolating rare cells in the blood.

BiotechnologyHealth CareHealth DiagnosticsMedical Device
Series UnknownJun 27, 2024
Amount Raised: $20,000,000
AtaCor Medical

San Clemente, California, United States

AtaCor Medical is a medical device maker.

Health CareMedical Device
Series CApr 24, 2024
Amount Raised: $28,000,000
ViaLase

Corona Del Mar, California, United States

ViaLase develops an image-guided femtosecond laser surgical system for the treatment of glaucoma.

Health CareMedical DeviceWellness
Series CApr 1, 2024
Amount Raised: $40,000,000
Flosonics

Sudbury, Ontario, Canada

Flosonics is a medical device company that focuses on developing non-invasive sensors to improve the management of critically ill patients.

Health CareMedicalMedical Device
Series CMar 19, 2024
Amount Raised: $20,000,000
Reprieve Cardiovascular

Milford, Massachusetts, United States

Reprieve Cardiovascular is focused on improving outcomes for patients suffering from acute decompensated heart failure.

Health CareMedical DeviceWellness
Series AFeb 20, 2024
Amount Raised: $42,000,000