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CLI Ventures

North America, California, United States, Palo Alto

Description

CLI Ventures is a Palo Alto, California-based venture capital firm specializing in early-stage investments across the global technology and healthcare sectors. Established in 2022, the firm targets companies from Seed to Series A rounds that are developing disruptive technologies and innovative solutions. Their investment thesis centers on high-growth areas including Artificial Intelligence (AI), Biotechnology, Digital Health, Enterprise SaaS, and Fintech, reflecting a broad yet focused approach to emerging markets.

The firm's investment strategy is characterized by its commitment to providing not just capital but also comprehensive support to its portfolio companies. CLI Ventures typically deploys initial checks ranging from $500,000 to $3,000,000, with additional capital reserved for follow-on rounds to support continued growth. This range positions them as a significant early-stage investor capable of fueling initial product development and market entry for promising startups. Beyond financial backing, CLI Ventures emphasizes strategic guidance, operational support, and access to their extensive network, aiming to accelerate the global scaling of their portfolio companies.

Despite being a relatively new entrant in the venture capital landscape, having been founded in 2022, CLI Ventures has quickly established a clear investment mandate. Their focus on global expansion for portfolio companies, even from their Silicon Valley base, highlights a forward-thinking approach to market opportunities. By concentrating on critical sectors like AI and biotech, they align with major innovation trends. The firm's hands-on approach and commitment to post-investment support are designed to foster long-term success and help founders navigate the complexities of scaling a technology or healthcare venture.

Investor Profile

CLI Ventures has backed more than 22 startups, with 0 new investments in the last 12 months alone. The firm has led 0 rounds, about 0% of its total and boasts 6 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Seed, Convertible Note, Series A rounds (top funding stages).
  • Majority of deals are located in United States.
  • Strong thematic focus on Software, Biotechnology, Health Care.
  • Typical check size: $500K – $3M.

Stage Focus

  • Seed (45%)
  • Convertible Note (14%)
  • Series A (14%)
  • Series C (9%)
  • Series B (9%)
  • Series Unknown (5%)
  • Pre Seed (5%)

Country Focus

  • United States (100%)

Industry Focus

  • Software
  • Biotechnology
  • Health Care
  • Robotics
  • Big Data
  • Artificial Intelligence (Ai)
  • E-commerce
  • Logistics
  • Mobile
  • Saas
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does CLI Ventures frequently co-invest with?

TSVC
North America, California, United States, Los Altos
Co-Investments: 2
Motus Ventures
North America, California, United States, Redwood City
Co-Investments: 1
IDG Capital
Asia, Beijing, China, Beijing
Co-Investments: 2
Zillionize
North America, California, United States, Palo Alto
Co-Investments: 3
Co-Investments: 1
Y Combinator
North America, California, United States, Mountain View
Co-Investments: 2
AngelPad
North America, California, United States, San Francisco
Co-Investments: 3
First Star Ventures
North America, Massachusetts, United States, Cambridge
Co-Investments: 2
Andreessen Horowitz
North America, California, United States, Menlo Park
Co-Investments: 2
Khosla Ventures
North America, California, United States, Menlo Park
Co-Investments: 2

Which angels does CLI Ventures often collaborate with?

JJ
North America, Arkansas, United States, Fayetteville
Shared Deals: 1
JH
North America, Nevada, United States, Incline Village
Shared Deals: 1
NM
North America, United States
Shared Deals: 2
CP
North America, Texas, United States, Austin
Shared Deals: 1
Joseph Hlady
North America, Alberta, Canada, Calgary
Shared Deals: 1
AA
North America, California, United States, San Francisco
Shared Deals: 1
Shinji Kimura
Asia, Tokyo, Japan, Tokyo
Shared Deals: 1
Daphne Teo
Asia, Singapore
Shared Deals: 1
RS
North America, Massachusetts, United States, Boston
Shared Deals: 1
RN
North America, California, United States, San Francisco
Shared Deals: 1

What are some of recent deals done by CLI Ventures?

Synlogic

Cambridge, Massachusetts, United States

Synlogic is a biotechnology company that develops synthetic biotic medicines to perform metabolic functions to treat diseases.

BiotechnologyHealth CareTherapeutics
Series CMay 16, 2017
Amount Raised: $42,000,000
Immune-Onc Therapeutics

Palo Alto, California, United States

Immune-Onc Therapeutics is a newly established biopharmaceutical company that develops therapeutic antibodies for cancer treatment.

BiopharmaBiotechnologyHealth CareMedicalOncologyTherapeutics
Series ASep 1, 2016
Amount Raised: $7,000,000
Eonite Perception

Palo Alto, California, United States

Eonite Perception is a 3D mapping and tracking company on a mission to enable machines to understand the real world.

3D TechnologyAugmented RealityRoboticsSoftwareVirtual Reality
SeedMay 5, 2016
Amount Raised: $5,250,000
Aria Pharmaceuticals

Palo Alto, California, United States

Aria Pharmaceuticals is a artificial intelligence-driven biopharmaceutical company.

Artificial Intelligence (AI)Big DataBiotechnologyHealth CarePharmaceutical
SeedNov 19, 2015
Amount Raised: $3,400,000
Civil Maps

San Francisco, California, United States

Civil Maps Provides a Sensor-agnostic Cognition Platform and Pipeline that Enables City Scale HD 3D Mapping, Edge Mapping and Localization.

Artificial Intelligence (AI)Autonomous VehiclesRoboticsSoftware
Convertible NoteSep 12, 2015
Amount Raised: $1,500,000
Skydrop

Reno, Nevada, United States

Flirtey provides drone delivery service of retail and e-commerce items to consumer homes.

Delivery ServiceE-CommerceLogisticsRoboticsTransportation
Series UnknownSep 7, 2015
Genalyte

San Diego, California, United States

Genalyte is a life sciences company developing and commercializing innovative next-generation multiplexing technology.

BiotechnologyHealth CareHospital
Series CAug 18, 2015
Amount Raised: $44,000,000
iMicrobes

Alameda, California, United States

Sustainable Materials from Greenhouse Gases using Biomanufacturing

BiotechnologyChemical
Pre SeedJun 15, 2015
Amount Raised: $120,000
CoPromote

New York, New York, United States

CoPromote operates as a free content sharing community.

Mobile AdvertisingSocial MediaSocial Media Marketing
Series AJun 2, 2015
Amount Raised: $480,623
InsideMaps

Mountain View, California, United States

InsideMaps is a smartphone and tablet app that enables anyone to easily create photorealistic 3D models and virtual tours of their homes.

3D TechnologyAppsInterior DesignMobileMobile AppsProperty ManagementReal Estate
SeedJun 1, 2015