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Commodore Capital

North America, New York, United States, New York

Description

Commodore Capital is a New York-based healthcare-focused investment firm dedicated to partnering with disruptive biopharmaceutical companies. The firm's core thesis revolves around identifying and supporting early-stage ventures that are at the forefront of major innovation cycles in drug discovery and development. They aim to accelerate the creation of novel medicines by providing not only capital but also strategic guidance and industry expertise to their portfolio companies. Their investment strategy is deeply rooted in a specialized understanding of the complex biopharmaceutical landscape, targeting companies with promising platforms and therapeutic candidates.

The firm has demonstrated significant growth in its capital deployment capabilities since its inception. Commodore Capital successfully closed its inaugural fund, Fund I, at $150 million in 2020, establishing its presence in the competitive biotech investment space. This was followed by the closing of Fund II at $300 million in 2022, underscoring increasing investor confidence and the firm's expanding capacity. Most recently, Commodore Capital announced the closing of its third fund, Fund III, at an impressive $400 million in 2024, bringing their total assets under management to approximately $850 million. This consistent growth in fund size enables them to make substantial commitments to their portfolio.

Commodore Capital typically invests across the early stages of biopharmaceutical development, including Seed, Series A, and Series B rounds. They are known for their hands-on approach, often taking a lead or co-lead position in funding rounds, which allows them to play a pivotal role in shaping the strategic direction of their portfolio companies. Their investment philosophy emphasizes long-term partnerships, providing the necessary capital and operational support to navigate the challenging path from preclinical research to clinical development. The firm's focus on groundbreaking science and its ability to commit significant capital make it a key player for innovative biopharma startups seeking substantial early-stage funding.

Investor Profile

Commodore Capital has backed more than 34 startups, with 6 new investments in the last 12 months alone. The firm has led 4 rounds, about 12% of its total and boasts 22 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Post Ipo Equity, Series B, Series C rounds (top funding stages).
  • Majority of deals are located in United States, Canada, United Kingdom.
  • Strong thematic focus on Biotechnology, Health Care, Therapeutics.
  • Led 1 rounds in the past year.
  • Typical check size: $5M – $25M.

Stage Focus

  • Post Ipo Equity (71%)
  • Series B (12%)
  • Series C (3%)
  • Seed (3%)
  • Series Unknown (3%)
  • Private Equity (3%)
  • Series A (3%)
  • Undisclosed (3%)

Country Focus

  • United States (88%)
  • Canada (3%)
  • United Kingdom (3%)
  • France (3%)

Industry Focus

  • Biotechnology
  • Health Care
  • Therapeutics
  • Medical
  • Pharmaceutical
  • Life Science
  • Health Diagnostics
  • Oncology
  • Biopharma
  • Clinical Trials
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does Commodore Capital frequently co-invest with?

Surveyor Capital
North America, Illinois, United States, Chicago
Co-Investments: 8
Venrock Healthcare Capital Partners
North America, California, United States, Palo Alto
Co-Investments: 12
RTW Investments
North America, New York, United States, New York
Co-Investments: 11
Biotechnology Value Fund
North America, California, United States, San Francisco
Co-Investments: 9
RA Capital Management
North America, Massachusetts, United States, Boston
Co-Investments: 10
Deep Track Capital
North America, Connecticut, United States, Greenwich
Co-Investments: 12
Fairmount Funds Management
North America, Pennsylvania, United States, Philadelphia
Co-Investments: 8
Perceptive Advisors
North America, New York, United States, New York
Co-Investments: 11
Logos Capital
North America, California, United States, San Francisco
Co-Investments: 13
Boxer Capital
North America, Florida, United States, Windermere
Co-Investments: 10

Which angels does Commodore Capital often collaborate with?

CC
North America, United States
Shared Deals: 1
JM
North America, Oregon, United States, Portland
Shared Deals: 1
Shared Deals: 1
DH
North America, California, United States, Los Angeles
Shared Deals: 1
Shared Deals: 1
CR
North America, California, United States, San Francisco
Shared Deals: 1
EB
North America, California, United States, San Francisco
Shared Deals: 1
DP
North America, United States
Shared Deals: 1
AG
North America, Oklahoma, United States, Norman
Shared Deals: 1
Shared Deals: 1

What are some of recent deals done by Commodore Capital?

SAB Biotherapeutics

Sioux Falls, South Dakota, United States

SAB Biotherapeutics is a clinical-stage biopharmaceutical development company.

BiotechnologyClinical TrialsTherapeutics
Post Ipo EquityJul 21, 2025
Amount Raised: $175,000,000
Crescent Biopharma

Rockville, Maryland, United States

Crescent Biopharma is a biotechnology firm focused on developing novel precision-engineered medicines.

BiotechnologyHealth CareMedical Device
Post Ipo EquityJun 16, 2025
Amount Raised: $200,000,000
Neurogene

New York, New York, United States

Neurogene is a developer of genetic medicines intended to improve patient outcomes for neurological disorders.

Biotechnology
Post Ipo EquityNov 4, 2024
Amount Raised: $200,000,000

Crescent Biopharma is a biotechnology firm focused on developing novel precision-engineered medicines.

BiotechnologyHealth CareMedical Device
UndisclosedOct 29, 2024
Amount Raised: $200,000,000
Inhibikase Therapeutics

Atlanta, Georgia, United States

Inhibikase Therapeutics is a developer of cellular Abelson tyrosine kinase inhibitors to treat infections and other diseases.

Health CareHealth DiagnosticsTherapeutics
Post Ipo EquityOct 9, 2024
Amount Raised: $110,000,000
Oruka Therapeutics

Waltham, Massachusetts, United States

Oruka Therapeutics is advancing innovative biologics to redefine patient care standards in chronic skin diseases.

BiotechnologyHealth CareMedical
Post Ipo EquitySep 3, 2024
Amount Raised: $275,000,000
Idrx

Plymouth, Massachusetts, United States

Idrx is a clinical-stage biopharmaceutical company dedicated to transforming cancer treatment.

BiotechnologyLife ScienceOncologyProduct Research
Series BAug 7, 2024
Amount Raised: $120,000,000
Avalo Therapeutics

Rockville, Maryland, United States

Avalo Therapeutics is a clinical-stage biopharmaceutical company.

BiotechnologyTherapeutics
Post Ipo EquityMar 27, 2024
Amount Raised: $115,600,000
Nkarta Therapeutics

South San Francisco, California, United States

Nkarta Therapeutics is a developer of cell engineering platform created to build the next generation of cell therapies.

BiotechnologyHealth Care
Post Ipo EquityMar 25, 2024
Amount Raised: $240,000,000
Enliven Therapeutics

Boulder, Colorado, United States

Enliven Therapeutics is a precision oncology company developing small molecule therapies to extend and improve patient lives.

BiotechnologyLife ScienceOncologyTherapeutics
Post Ipo EquityMar 19, 2024
Amount Raised: $90,000,000