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NSF Small Business Innovation Research / Small Business Technology Transfer (SBIR/STTR)

North America, Virginia, United States, Arlington

Description

The National Science Foundation (NSF) Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) program is a crucial federal grant initiative, distinct from traditional venture capital, designed to support high-risk, high-reward technological innovations. Its primary mission is to stimulate technological innovation, foster commercialization of federally funded research, and encourage the participation of small businesses in federal R&D. This non-dilutive funding mechanism allows startups to develop groundbreaking technologies without ceding equity, making it a highly attractive source of capital for early-stage companies focused on deep science and engineering.

The NSF SBIR/STTR program operates in two main phases. Phase I grants are awarded for proof-of-concept and feasibility studies, typically providing up to $275,000 to validate the technical merit and commercial potential of an idea. Successful Phase I awardees are then eligible to apply for Phase II funding, which supports full-scale research and development efforts aimed at bringing the technology closer to commercialization. Phase II grants can be substantial, often reaching up to $1,000,000, allowing companies to significantly de-risk their technology and attract follow-on private investment.

NSF SBIR/STTR focuses on a broad range of technology areas, emphasizing projects with strong scientific merit and clear pathways to societal and economic impact. The program plays a vital role in bridging the gap between fundamental research and market-ready products, enabling small businesses to tackle complex challenges and create new industries. For instance, in Fiscal Year 2023, the NSF awarded over $200 million in SBIR/STTR grants to hundreds of small businesses, underscoring its significant contribution to job creation and the growth of the U.S. innovation economy.

Investor Profile

NSF Small Business Innovation Research / Small Business Technology Transfer (SBIR/STTR) has backed more than 66 startups, with 4 new investments in the last 12 months alone. The firm has led 50 rounds, about 76% of its total and boasts 5 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Grant, Pre Seed, Seed rounds (top funding stages).
  • Majority of deals are located in United States.
  • Strong thematic focus on Health Care, Biotechnology, Artificial Intelligence (AI).
  • Led 4 rounds in the past year.
  • Typical check size: $150K – $275K.

Stage Focus

  • Grant (88%)
  • Pre Seed (8%)
  • Seed (3%)
  • Angel (2%)

Country Focus

  • United States (97%)

Industry Focus

  • Health Care
  • Biotechnology
  • Artificial Intelligence (Ai)
  • Machine Learning
  • Software
  • Medical
  • Information Technology
  • Medical Device
  • Life Science
  • Manufacturing
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does NSF Small Business Innovation Research / Small Business Technology Transfer (SBIR/STTR) frequently co-invest with?

Oregon State University
North America, Oregon, United States, Corvallis
Co-Investments: 1
Pear VC
North America, California, United States, Menlo Park
Co-Investments: 1
Techstars
North America, Colorado, United States, Boulder
Co-Investments: 1
focal
North America, California, United States, San Francisco
Co-Investments: 1
OnDeck Venture
Asia, Hong Kong Island, Hong Kong, Central
Co-Investments: 1

Which angels does NSF Small Business Innovation Research / Small Business Technology Transfer (SBIR/STTR) often collaborate with?

GP
North America, California, United States, Fremont
Shared Deals: 1

What are some of recent deals done by NSF Small Business Innovation Research / Small Business Technology Transfer (SBIR/STTR)?

GIANT BioSystems

Los Angeles, California, United States

GIANT BioSystems is a developer of an ultra-fast, next-generation platform for AST and high-throughput drug screening.

Artificial Intelligence (AI)Health CareHealth DiagnosticsMachine LearningMedical Device
GrantMar 1, 2025
Amount Raised: $305,000
GeniPhys

Zionsville, Indiana, United States

GeniPhys is a medical technology company that plans to develop and commercialize its patented technology.

Health CareMedicalMedical Device
GrantOct 22, 2024
Amount Raised: $500,000
Silvis Materials

Boulder, Colorado, United States

Sustainable, bio-degradable adhesives and binders

Building MaterialChemicalChemical EngineeringIndustrial Manufacturing
GrantSep 18, 2024
Amount Raised: $1,000,000
Actualization.AI

Tampa, Florida, United States

Chatbot confidence. Actualization.AI specializes in chatbot security, efficiently finding vulnerabilities so that they can be fixed.

Artificial Intelligence (AI)ChatbotCyber SecurityMachine LearningNatural Language Processing
Pre SeedSep 1, 2024
Amount Raised: $275,000

Quarksen develops eQuanta, a creative sensing technology for accessible, accurate, and quick at-home diagnostics.

Health DiagnosticsMedical
GrantJul 11, 2024
EarthEn

Phoenix, Arizona, United States

EarthEn works on technology to provide a carbon-negative, climate-positive long-duration energy storage solution.

Electrical DistributionEnergyEnergy Storage
GrantJul 9, 2024

AI-driven platform assists product managers, designers, and related professionals in having better insights into customers' needs

GrantJun 4, 2024
Amount Raised: $275,000
Softhread

Baltimore, Maryland, United States

Softhread is a blockchain technology company that develops enterprise solutions using a blockchain and AI-enabled platform.

Artificial Intelligence (AI)BlockchainCyber Security
GrantMay 22, 2024
Amount Raised: $1,000,000
MathBRIX

St Louis, Missouri, United States

MathBRIX is a highly visual, concept-based approach to teaching math, backed by decades of research.

AssociationE-LearningEducationNon ProfitSaaSWeb Design
GrantFeb 21, 2024
Amount Raised: $1,000,000
Lunexus Space

Denver, Colorado, United States

Energizing the Circular Economy in Space

Clean EnergyManufacturingSatellite Communication
GrantJan 25, 2024
Amount Raised: $275,000