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OrbiMed

North America, New York, United States, New York

Description

OrbiMed is a preeminent global investment firm exclusively dedicated to the healthcare sector, headquartered in New York City. Established with a singular focus on healthcare, the firm employs a comprehensive investment strategy that spans the entire industry, from early-stage venture capital to growth equity, public equity, and credit investments. This broad mandate allows OrbiMed to support companies at virtually every stage of their lifecycle, fostering innovation and growth across biopharmaceuticals, medical devices, diagnostics, and digital health solutions worldwide. Their deep industry expertise and extensive network are central to their value proposition, enabling them to identify and nurture promising healthcare ventures.

The firm's investment approach is characterized by its long-term perspective and a commitment to partnering with management teams to build successful enterprises. OrbiMed's global presence, with offices in major financial and biotech hubs, facilitates a diverse portfolio that reflects the dynamic nature of the healthcare landscape. As of early 2024, OrbiMed manages approximately $18 billion in assets, underscoring its significant financial capacity and influence within the healthcare investment ecosystem. This substantial capital base allows them to deploy considerable resources into both emerging and established companies, driving significant advancements in patient care and medical technology.

OrbiMed's typical first cheque sizes are reflective of its multi-stage investment strategy and the substantial capital it manages. While they participate in seed and early-stage venture rounds, their significant private equity funds enable larger commitments. For instance, in 2022, the firm closed its OrbiMed Private Investments IX fund with $4.3 billion in capital commitments, demonstrating their capacity for substantial investments. Consequently, a typical first cheque for a private company can range widely, often starting from around $10 million for early-stage venture deals and extending up to $200 million or more for growth equity or later-stage private investments, particularly when taking a lead or significant co-lead position in a funding round. This flexibility allows them to tailor their investment to the specific needs and stage of the target company, from innovative startups to established market leaders.

Investor Profile

OrbiMed has backed more than 693 startups, with 39 new investments in the last 12 months alone. The firm has led 231 rounds, about 33% of its total and boasts 252 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series B, Series A, Series C rounds (top funding stages).
  • Majority of deals are located in United States, China, Israel.
  • Strong thematic focus on Biotechnology, Health Care, Medical.
  • Led 10 rounds in the past year.
  • Typical check size: $10M – $200M.

Stage Focus

  • Series B (23%)
  • Series A (19%)
  • Series C (17%)
  • Post Ipo Equity (12%)
  • Series Unknown (11%)
  • Series D (7%)
  • Series E (3%)
  • Series F (2%)
  • Post Ipo Debt (2%)
  • Private Equity (2%)

Country Focus

  • United States (71%)
  • China (8%)
  • Israel (7%)
  • Canada (3%)
  • United Kingdom (3%)
  • India (2%)
  • Switzerland (2%)
  • France (2%)
  • Germany (1%)
  • Denmark (1%)

Industry Focus

  • Biotechnology
  • Health Care
  • Medical
  • Pharmaceutical
  • Therapeutics
  • Biopharma
  • Medical Device
  • Life Science
  • Health Diagnostics
  • Oncology
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does OrbiMed frequently co-invest with?

HBM Healthcare Investments
Europe, Zug, Switzerland, Zug
Co-Investments: 30
Surveyor Capital
North America, Illinois, United States, Chicago
Co-Investments: 35
CA
North America, Massachusetts, United States, Boston
Co-Investments: 41
RA Capital Management
North America, Massachusetts, United States, Boston
Co-Investments: 71
Novo Holdings
Europe, Hovedstaden, Denmark, Hellerup
Co-Investments: 31
Foresite Capital
North America, California, United States, San Francisco
Co-Investments: 35
Vivo Capital
North America, California, United States, Palo Alto
Co-Investments: 37
Logos Capital
North America, California, United States, San Francisco
Co-Investments: 33
Lilly Asia Ventures
Asia, Shanghai, China, Shanghai
Co-Investments: 35
Fidelity
North America, Massachusetts, United States, Boston
Co-Investments: 31

Which angels does OrbiMed often collaborate with?

RA
North America, United States
Shared Deals: 1
ME
Europe, England, United Kingdom
Shared Deals: 1
PT
North America, California, United States, San Francisco
Shared Deals: 3
AU
Europe, Hallands Lan, Sweden, Kungsbacka
Shared Deals: 1
Mark W. Hahn
North America, North Carolina, United States, Chapel Hill
Shared Deals: 1
Zohar Zisapel
Asia, Tel Aviv, Israel, Tel Aviv
Shared Deals: 2
VS
North America, Massachusetts, United States, Boston
Shared Deals: 1
LB
North America, Massachusetts, United States, Cambridge
Shared Deals: 2
David Zaccardelli
North America, United States
Shared Deals: 1
DE
Europe, Zurich, Switzerland, Zürich
Shared Deals: 1

What are some of recent deals done by OrbiMed?

Myriad Genetics

Salt Lake City, Utah, United States

Myriad Genetics discovers, develops, and commercializing novel therapies for the treatment of cancer.

BiotechnologyPharmaceuticalPrecision Medicine
Post Ipo DebtJul 31, 2025
Amount Raised: $125,000,000
InspireMD

Miami, Florida, United States

InspireMD is a medical device company focusing on the development and commercialization of its proprietary stent system technology, MGuard.

BiopharmaBiotechnologyHealth CareMedical Device
Post Ipo EquityJul 31, 2025
Amount Raised: $58,000,000
Inmagene Biopharmaceuticals

San Diego, California, United States

Inmagene is a clinical-stage biotech company developing innovative and differentiated therapies for immunological and inflammatory diseases.

BiopharmaBiotechnologyHealth Care
Post Ipo EquityJul 28, 2025
Amount Raised: $75,000,000
vVardis

Baar, Zug, Switzerland

vVardis is a personal oral care brand by Dres Abivardi.

DentalHealth CareMedicalMedical Device
Series UnknownJul 15, 2025
Amount Raised: $50,000,000
Renasant Bio

Berkeley, California, United States

Renasant Bio is a biopharmaceutical company pioneering disease-modifying oral small molecule treatments.

BiotechnologyLife ScienceTherapeutics
SeedJul 10, 2025
Amount Raised: $54,500,000
Alpheus Medical

Oakdale, Pennsylvania, United States

Alpheus Medical provides a novel sonodynamic therapy platform targeting solid body cancers.

BiotechnologyHealth CareHealth DiagnosticsMedical
Series BMay 15, 2025
Amount Raised: $52,000,000
CytomX Therapeutics

South San Francisco, California, United States

CytomX Therapeutics is a biotechnology company that focuses on developing proteolytically-activated antibodies.

BiotechnologyHealth CarePharmaceuticalTherapeutics
Post Ipo EquityMay 12, 2025
Amount Raised: $100,000,000
Sirius Therapeutics

San Diego, California, United States

Sirius Therapeutics is an innovative biotechnology company that focuses on RNAi therapies for cardiovascular diseases.

BiotechnologyPharmaceuticalTherapeutics
Series BMay 9, 2025
Amount Raised: $50,000,000
Fore Biotherapeutics

Philadelphia, Pennsylvania, United States

Fore Biotherapeutics is a precision oncology company specializing in cancer therapies guided by functional genomics.

BiotechnologyHealth CareHealth DiagnosticsMedicalOncology
Series DMay 6, 2025
Amount Raised: $38,000,000
Jade Biosciences

Waltham, Massachusetts, United States

Jade Biosciences is developing transformative therapies to redefine the standard of care for inflammation and immunology indications.

Health CareTherapeutics
Post Ipo EquityApr 29, 2025
Amount Raised: $300,000,000