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OS Fund

North America, Illinois, United States, Chicago

Description

OS Fund, based in Chicago, is a venture capital firm founded by Bryan Johnson, a serial entrepreneur best known for founding Braintree, which was acquired by PayPal for $800 million. The firm's core mission is to invest in entrepreneurs, inventors, and scientists who are "rewriting the operating systems of life" to benefit humanity. This unique thesis positions OS Fund at the forefront of deep technology and frontier science investments.

The firm's investment focus spans a wide array of groundbreaking sectors, including synthetic biology, artificial intelligence, robotics, new materials, space exploration, and human augmentation. They seek out companies that are developing fundamental technologies with the potential for transformative impact across multiple industries. OS Fund emphasizes long-term vision and supports founders who are tackling complex, foundational problems rather than incremental improvements.

OS Fund primarily targets early-stage companies, typically participating in seed and Series A rounds. The firm has demonstrated significant capital commitment, having successfully raised at least three distinct funds, each reportedly sized at $100 million, bringing their total capital under management to approximately $300 million. Their typical initial investment ranges from $500,000 to $5 million, reflecting their strategy of providing substantial early capital to highly ambitious ventures. This approach allows them to support companies from their foundational stages through significant growth milestones, fostering innovation in critical scientific and technological domains.

Investor Profile

OS Fund has backed more than 45 startups, with 0 new investments in the last 12 months alone. The firm has led 6 rounds, about 13% of its total and boasts 10 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Seed, Series A, Series B rounds (top funding stages).
  • Majority of deals are located in United States, Canada.
  • Strong thematic focus on Biotechnology, Health Care, Medical.
  • Typical check size: $500K – $5M.

Stage Focus

  • Seed (33%)
  • Series A (29%)
  • Series B (24%)
  • Series Unknown (4%)
  • Series D (4%)
  • Series C (2%)
  • Pre Seed (2%)

Country Focus

  • United States (91%)
  • Canada (9%)

Industry Focus

  • Biotechnology
  • Health Care
  • Medical
  • Health Diagnostics
  • Genetics
  • Artificial Intelligence (Ai)
  • Machine Learning
  • Life Science
  • Information Technology
  • Therapeutics
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does OS Fund frequently co-invest with?

Vast Ventures
North America, New York, United States, New York
Co-Investments: 4
Draper Associates
North America, California, United States, San Mateo
Co-Investments: 5
Felicis
North America, California, United States, Menlo Park
Co-Investments: 3
Y Combinator
North America, California, United States, Mountain View
Co-Investments: 8
AME Cloud Ventures
North America, California, United States, Palo Alto
Co-Investments: 6
Wilson Sonsini Goodrich & Rosati
North America, California, United States, Palo Alto
Co-Investments: 4
Fifty Years
North America, California, United States, San Francisco
Co-Investments: 3
DCVC
North America, California, United States, San Francisco
Co-Investments: 8
Founders Fund
North America, California, United States, San Francisco
Co-Investments: 6
Khosla Ventures
North America, California, United States, Menlo Park
Co-Investments: 4

Which angels does OS Fund often collaborate with?

DM
North America, California, United States, San Francisco
Shared Deals: 1
BV
North America, California, United States, Los Angeles
Shared Deals: 1
Daniel Curran
North America, California, United States, Santa Monica
Shared Deals: 2
AL
North America, California, United States
Shared Deals: 1
JD
North America, California, United States, San Francisco
Shared Deals: 1
MZ
North America, California, United States, Palo Alto
Shared Deals: 1
JD
North America, California, United States, San Francisco
Shared Deals: 1
FN
North America, California, United States, Menlo Park
Shared Deals: 2
Shared Deals: 1
Shared Deals: 1

What are some of recent deals done by OS Fund?

Arzeda

Seattle, Washington, United States

We harness the power of Intelligent Protein Design Technology™ to create enzyme products solving industry's toughest challenges

BiotechnologyInformation ServicesInformation TechnologyManufacturing
Series BMar 29, 2022
Amount Raised: $33,000,000
Kenota Health

Kitchener, Ontario, Canada

Kenota Health develops next-generation diagnostic tools intended to be used for allergy testing in humans.

BiotechnologyHealth CareHealth DiagnosticsMedical
Series ADec 7, 2020
Amount Raised: $9,000,000
A-Alpha Bio

Seattle, Washington, United States

A-Alpha Bio uses synthetic biology and machine learning to measure, discover, predict, and engineer protein-protein interactions.

BiotechnologyHealth CareLife ScienceTherapeutics
SeedSep 24, 2019
Amount Raised: $2,800,000
GRO Biosciences

Boston, Massachusetts, United States

GRO Biosciences is a biotechnology company that develops a protein therapeutics technology to improve treatments across multiple diseases.

BiotechnologyHealth DiagnosticsMedicalPharmaceuticalTherapeutics
SeedMar 13, 2019
Amount Raised: $3,500,000
Verge Genomics

San Francisco, California, United States

Verge Genomics uses machine learning and human genomics to accelerate drug discovery.

BiotechnologyGeneticsHealth CareMachine LearningNeuroscience
Series AJul 17, 2018
Amount Raised: $32,000,000
Lygos

Berkeley, California, United States

Lygos provides biotechnology solutions for today’s renewable chemical challenges.

Advanced MaterialsBiotechnologyClean Energy
Series BJul 17, 2018
Amount Raised: $15,500,000
Catalog

Boston, Massachusetts, United States

Catalog is a developer of a data conversion and storage platform used to offer the next generation of digital data archives.

AnalyticsBiotechnologyData StorageInformation ServicesInformation TechnologySoftware
SeedJun 26, 2018
Amount Raised: $4,000,000
NuMat Technologies

Skokie, Illinois, United States

NuMat Technologies builts an Operating System for the commercialization of programmable chemistries.

HardwareNanotechnologyRenewable EnergySemiconductor
Series BApr 26, 2018
Amount Raised: $12,400,000
Aria Pharmaceuticals

Palo Alto, California, United States

Aria Pharmaceuticals is a artificial intelligence-driven biopharmaceutical company.

Artificial Intelligence (AI)Big DataBiotechnologyHealth CarePharmaceutical
Series AMar 19, 2018
Amount Raised: $10,000,000
GRO Biosciences

Boston, Massachusetts, United States

GRO Biosciences is a biotechnology company that develops a protein therapeutics technology to improve treatments across multiple diseases.

BiotechnologyHealth DiagnosticsMedicalPharmaceuticalTherapeutics
SeedFeb 8, 2018
Amount Raised: $2,400,000