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The Engine

North America, Massachusetts, United States, Cambridge

Description

The Engine, an MIT-founded venture firm based in Cambridge, Massachusetts, is dedicated to supporting "tough tech" startups. Its core mission is to bridge the critical gap between scientific discovery and commercialization, providing essential capital, infrastructure, and expertise to companies tackling some of the world's most significant challenges in areas such as climate change, human health, advanced systems, and industrial technology. The firm's unique approach emphasizes the long-term development of groundbreaking scientific and engineering solutions.

The Engine primarily invests in seed and Series A stage companies, recognizing the substantial capital and time required for deep tech ventures to mature. The firm has demonstrated significant growth in its funding capacity, launching its third fund in 2023 with $390 million, which brought its total assets under management to over $800 million across three funds. This financial backing enables The Engine to provide crucial early-stage support, often acting as the first institutional investor for these capital-intensive startups.

Beyond financial investment, The Engine distinguishes itself by offering extensive operational support, including access to specialized labs, prototyping facilities, and office space within its Cambridge headquarters. This integrated ecosystem is designed to accelerate the development of complex technologies, providing a unique environment for innovation. The firm has built a robust portfolio of over 60 companies, each working on transformative innovations that aim to create new industries and solve pressing societal problems. Their typical initial investment ranges from $1 million to $5 million, reflecting their commitment to foundational support for these ventures.

Investor Profile

The Engine has backed more than 72 startups, with 2 new investments in the last 12 months alone. The firm has led 25 rounds, about 35% of its total and boasts 1 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Seed, Series A, Series B rounds (top funding stages).
  • Majority of deals are located in United States.
  • Strong thematic focus on Biotechnology, Health Care, Software.
  • Typical check size: $1M – $5M.

Stage Focus

  • Seed (33%)
  • Series A (29%)
  • Series B (18%)
  • Pre Seed (7%)
  • Series Unknown (6%)
  • Series C (3%)
  • Series D (1%)
  • Series E (1%)
  • Non Equity Assistance (1%)

Country Focus

  • United States (100%)

Industry Focus

  • Biotechnology
  • Health Care
  • Software
  • Energy
  • Renewable Energy
  • Environmental Engineering
  • Medical
  • Manufacturing
  • Energy Storage
  • Advanced Materials
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does The Engine frequently co-invest with?

SP
North America, Massachusetts, United States, Cambridge
Co-Investments: 8
Fine Structure Venture
North America, Massachusetts, United States, Boston
Co-Investments: 7
Prelude Ventures
North America, California, United States, San Francisco
Co-Investments: 12
Refactor
North America, California, United States, Burlingame
Co-Investments: 5
Temasek Holdings
Asia, Central Region, Singapore, Singapore
Co-Investments: 6
Breakthrough Energy Ventures
Europe, Ile-de-France, France, Paris
Co-Investments: 14
Energy Impact Partners
North America, New York, United States, New York
Co-Investments: 5
Alumni Ventures
North America, New Hampshire, United States, Manchester
Co-Investments: 9
Khosla Ventures
North America, California, United States, Menlo Park
Co-Investments: 6
Blindspot Ventures
North America, Massachusetts, United States, Boston
Co-Investments: 8

Which angels does The Engine often collaborate with?

AP
North America, Maryland, United States, Bethesda
Shared Deals: 1
JD
North America, California, United States, Menlo Park
Shared Deals: 1
MC
North America, North Dakota, United States, Fargo
Shared Deals: 1
Shared Deals: 1
BG
North America, Washington, United States, Seattle
Shared Deals: 1
Alejandro Chavez
North America, Jalisco, Mexico, Guadalajara
Shared Deals: 1
DS
North America, New York, United States, Saint James
Shared Deals: 1
AS
North America, United States
Shared Deals: 1
SL
North America, Massachusetts, United States, Cambridge
Shared Deals: 1
JB
North America, North Dakota, United States, Fargo
Shared Deals: 1

What are some of recent deals done by The Engine?

BlueShift

Cambridge, Massachusetts, United States

BlueShift operates as an electrochemical climate tech innovator.

Assistive TechnologyMineralRecycling
Pre SeedMar 19, 2025
Amount Raised: $2,100,000
VEIR

Woburn, Massachusetts, United States

VEIR develops superconducting wires for electrical transmission that are used in data centers and renewable energy sectors.

Electrical DistributionPower GridSolar
Series BJan 28, 2025
Amount Raised: $75,000,000
Osmoses

Cambridge, Massachusetts, United States

Osmoses engages in decarbonizing gas separations to eliminate one gigaton of carbon emissions per year.

GreenTechIndustrial
SeedOct 3, 2023
Amount Raised: $11,000,000
Vaxess Technologies

Cambridge, Massachusetts, United States

Vaxess Technologies engages in developing biomedical innovations with a focus on improving access to vaccines.

BiotechnologyHealth CareMedical
Series UnknownSep 13, 2023
Amount Raised: $9,000,000
Amide Technologies

Cambridge, Massachusetts, United States

Amide Technologies offers on-demand complex peptide manufacturing at unprecedented speed.

Information Technology
Series AJul 28, 2023
Amount Raised: $7,500,000
Celestial AI

Santa Clara, California, United States

Celestial AI develops an optical interconnect technology platform for data center and AI computing solutions.

Artificial Intelligence (AI)Data CenterMachine LearningSemiconductorSoftware
Series BJun 28, 2023
Amount Raised: $100,000,000
Hyfé

Chicago, Illinois, United States

Hyfé produces low-cost feedstocks for biomanufacturing by valorizing waste carbons from food processing wastewater.

BiotechnologyChemical EngineeringFood and BeverageFood ProcessingManufacturingWaste Management
SeedJun 22, 2023
Amount Raised: $9,000,000
VEIR

Boston, Massachusetts, United States

VEIR is a company developing a new approach to using high-temperature superconductors for electricity transmission.

Electrical DistributionPower GridSolar
Series AMay 15, 2023
Amount Raised: $24,902,885
Droplet Biosciences

Cambridge, Massachusetts, United States

Droplet Biosciences can offer earlier and more accurate cancer diagnosis by using lymphatic fluid.

Health CareHealth DiagnosticsOncology
SeedMar 16, 2023
Amount Raised: $8,000,000
Sublime Systems

Somerville, Massachusetts, United States

Sublime Systems develops technology to decarbonize cement-making.

CleanTechEnergyRenewable Energy
Series AJan 17, 2023
Amount Raised: $40,000,000