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What If Ventures

North America, Texas, United States, Frisco

Description

What If Ventures is a dedicated venture capital firm based in Frisco, Texas, specializing in early-stage digital healthcare startups. Established in 2020, the firm has rapidly positioned itself as a key investor in the evolving health technology landscape, focusing on innovative solutions that address critical healthcare challenges. Their investment philosophy centers on identifying and nurturing companies that leverage technology to improve patient outcomes, enhance care delivery, and increase accessibility within the healthcare system.

The firm operates with a clear investment mandate, primarily targeting companies from the seed to Series A stages, though their stated interest extends up to pre-IPO for follow-on opportunities. What If Ventures manages a $10 million fund, which underpins their capacity to support promising ventures. They typically write initial checks ranging from $250,000 to $750,000, indicating a preference for significant early-stage participation. This strategic approach allows them to provide crucial capital for product development, market entry, and initial scaling for their portfolio companies.

What If Ventures maintains a broad yet focused interest across various sub-sectors within digital health. Their portfolio reflects a commitment to areas such as mental health, substance use disorder, chronic disease management, women's health, pediatrics, digital therapeutics, and the application of AI/ML in healthcare. As of early 2024, Crunchbase indicates that What If Ventures has made approximately 17 investments, demonstrating their active engagement in the market. The firm also reserves capital for follow-on rounds, signaling a long-term commitment to their portfolio companies' growth and success.

This structured investment approach, combined with a deep understanding of the digital health sector, positions What If Ventures as a valuable partner for founders seeking not just capital, but also strategic guidance and industry connections. Their focus on early-stage innovation in a rapidly expanding market underscores their potential to drive significant impact in the future of healthcare.

Investor Profile

What If Ventures has backed more than 82 startups, with 6 new investments in the last 12 months alone. The firm has led 0 rounds, about 0% of its total and boasts 5 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Seed, Series A, Series B rounds (top funding stages).
  • Majority of deals are located in United States, Canada, Germany.
  • Strong thematic focus on Health Care, Medical, Biotechnology.
  • Typical check size: $250K – $750K.

Stage Focus

  • Seed (26%)
  • Series A (21%)
  • Series B (17%)
  • Series C (13%)
  • Series Unknown (10%)
  • Convertible Note (5%)
  • Pre Seed (2%)
  • Series D (2%)
  • Series F (1%)
  • Secondary Market (1%)

Country Focus

  • United States (89%)
  • Canada (4%)
  • Germany (4%)
  • United Kingdom (2%)
  • Switzerland (1%)

Industry Focus

  • Health Care
  • Medical
  • Biotechnology
  • Mental Health
  • Wellness
  • Software
  • Life Science
  • Therapeutics
  • Artificial Intelligence (Ai)
  • Pharmaceutical
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does What If Ventures frequently co-invest with?

Gaingels
North America, Vermont, United States, Burlington
Co-Investments: 8
Korify Capital
Europe, Sicilia, Italy, Santa Venerina
Co-Investments: 4
FJ Labs
North America, New York, United States, New York
Co-Investments: 6
Google Ventures
North America, California, United States, Mountain View
Co-Investments: 5
Prime Movers Lab
North America, Wyoming, United States, Jackson
Co-Investments: 3
Able Partners
North America, New York, United States, New York
Co-Investments: 3
Presight Capital
North America, California, United States, West Hollywood
Co-Investments: 7
Andreessen Horowitz
North America, California, United States, Menlo Park
Co-Investments: 5
Alumni Ventures
North America, New Hampshire, United States, Manchester
Co-Investments: 5
Apeiron Investment Group
Europe, NA - Malta, Malta, Sliema
Co-Investments: 6

Which angels does What If Ventures often collaborate with?

JB
North America, California, United States, San Francisco
Shared Deals: 1
RS
North America, California, United States, San Francisco
Shared Deals: 1
SB
North America, California, United States
Shared Deals: 2
AP
Europe, England, United Kingdom, London
Shared Deals: 1
PT
North America, California, United States, San Francisco
Shared Deals: 2
JL
North America, Massachusetts, United States, Boston
Shared Deals: 2
DM
North America, California, United States, San Francisco
Shared Deals: 1
Ricardo Marino
South America, Sao Paulo, Brazil, São Paulo
Shared Deals: 1
GL
North America, Connecticut, United States, Hartford
Shared Deals: 1
AK
North America, California, United States, San Francisco
Shared Deals: 6

What are some of recent deals done by What If Ventures?

Saildrone

Alameda, California, United States

Saildrone is a maritime company that enables navies, governments, and organizations to obtain data required to monitor the maritime domain.

Artificial Intelligence (AI)Big DataDronesManufacturingMarine Technology
Series UnknownMay 13, 2025
Amount Raised: $60,000,000
Firehawk Aerospace

Addison, Texas, United States

Firehawk Aerospace designs and manufactures rocket motors powered by 3D printed propellant.

3D PrintingAerospaceManufacturing
Series CJan 5, 2025
Amount Raised: $60,000,000
Alto Pharmacy

San Francisco, California, United States

Alto is a digital pharmacy that makes the prescription experience easier.

ConsumerHealth CareMedicalPharmaceuticalSoftware
Convertible NoteNov 26, 2024
Raven Space Systems

Kansas City, Missouri, United States

Modernizing composite manufacturing with breakthrough 3D printing

3D PrintingAerospaceManufacturing
Pre SeedNov 20, 2024
Amount Raised: $2,000,000
Terray Therapeutics

Monrovia, California, United States

Terray Therapeutics is a biotechnology company that transforms small molecule drug discovery.

Artificial Intelligence (AI)BiopharmaBiotechnologyLife ScienceMedical
Series BOct 17, 2024
Amount Raised: $120,000,000
Slingshot AI

Albany, New York, United States

Slingshot AI provides a cloud-based platform for easy training, deploying, and managing machine learning models.

Artificial Intelligence (AI)Cloud Data ServicesSoftwareWeb Development
SeedAug 20, 2024
Amount Raised: $30,000,000
Grayce

San Francisco, California, United States

Grayce is a social care management platform that provides elderly care services to support and guide family caregivers.

Elder CaremHealthWellness
Series AJun 12, 2024
Amount Raised: $10,400,000
Two Chairs

San Francisco, California, United States

Two Chairs is a behavioral health company that operates a mental health therapy platform to offer in-person psychotherapy.

Health CareMental HealthTherapeuticsWellness
Series CApr 16, 2024
Amount Raised: $72,000,000
Save da Sea

Victoria, British Columbia, Canada

Save Da Sea provides plant-based seafood.

Alternative ProteinFood and BeverageFood ProcessingPlant-Based FoodsSeafood
SeedApr 1, 2024
Amount Raised: $478,851
Overture Life

New York, New York, United States

Overture Life is a biotechnology company committed to making vitro fertilization more accessible to everyone.

BiotechnologyFertilityHealth Care
Series BMar 31, 2024