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Zetta Venture Partners

North America, California, United States, San Francisco

Description

Zetta Venture Partners is a pioneering venture capital firm, distinguished as one of the first to exclusively focus on AI-first enterprise software companies. Based in San Francisco, the firm targets early-stage startups, primarily at the Seed and Series A stages, that are building intelligent applications leveraging machine learning and artificial intelligence to solve complex business problems. Their investment thesis centers on the belief that AI will fundamentally transform enterprise operations, creating new categories of software.

Zetta's approach goes beyond capital provision; they offer deep domain expertise in AI, operational guidance, and a network tailored to the unique challenges of developing and scaling AI-driven businesses. They look for companies with strong technical teams, proprietary data advantages, and clear pathways to market leadership in their niche. The firm actively supports its portfolio companies with strategic advice on product development, go-to-market strategies, and talent acquisition, all through an AI-centric lens.

Over the years, Zetta Venture Partners has steadily grown its capital base, reflecting its commitment and success in the AI sector. The firm closed its fourth fund, Zetta IV, in 2022 with $260 million, bringing its total assets under management to over $650 million across all funds. This substantial capital allows Zetta to make meaningful early-stage investments, with typical initial checks ranging from $2 million to $8 million. Their portfolio includes notable companies such as Domino Data Lab, Lilt, and Tractable, demonstrating their impact on the enterprise AI landscape.

Investor Profile

Zetta Venture Partners has backed more than 102 startups, with 7 new investments in the last 12 months alone. The firm has led 38 rounds, about 37% of its total and boasts 12 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Seed, Series A, Series B rounds (top funding stages).
  • Majority of deals are located in United States, United Kingdom, The Netherlands.
  • Strong thematic focus on Software, Artificial Intelligence (AI), Machine Learning.
  • Typical check size: $2M – $8M.

Stage Focus

  • Seed (40%)
  • Series A (31%)
  • Series B (12%)
  • Series C (5%)
  • Pre Seed (4%)
  • Series Unknown (3%)
  • Series D (2%)
  • Angel (1%)
  • Debt Financing (1%)
  • Convertible Note (1%)

Country Focus

  • United States (87%)
  • United Kingdom (5%)
  • The Netherlands (3%)
  • Spain (2%)
  • India (1%)
  • Australia (1%)
  • Canada (1%)

Industry Focus

  • Software
  • Artificial Intelligence (Ai)
  • Machine Learning
  • Analytics
  • Enterprise Software
  • Saas
  • Big Data
  • Information Technology
  • Developer Tools
  • Health Care
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does Zetta Venture Partners frequently co-invest with?

Sequoia Capital
North America, California, United States, Menlo Park
Co-Investments: 4
EPIC Ventures
North America, Utah, United States, Salt Lake City
Co-Investments: 5
Hummer Winblad Venture Partners
North America, California, United States, San Francisco
Co-Investments: 6
Glasswing Ventures
North America, Massachusetts, United States, Boston
Co-Investments: 7
Vertex Ventures
Asia, Central Region, Singapore, Singapore
Co-Investments: 4
Salesforce Ventures
North America, California, United States, San Francisco
Co-Investments: 4
Bloomberg Beta
North America, California, United States, San Francisco
Co-Investments: 10
Cathay Innovation
North America, California, United States, San Francisco
Co-Investments: 4
Polaris Partners
North America, Massachusetts, United States, Boston
Co-Investments: 8
Redpoint
North America, California, United States, Menlo Park
Co-Investments: 6

Which angels does Zetta Venture Partners often collaborate with?

CA
North America, Texas, United States, Austin
Shared Deals: 1
JM
North America, Wisconsin, United States, Milwaukee
Shared Deals: 2
SR
North America, California, United States, San Anselmo
Shared Deals: 1
AP
North America, California, United States, San Francisco
Shared Deals: 1
MB
North America, California, United States, San Francisco
Shared Deals: 2
EC
North America, California, United States, Palo Alto
Shared Deals: 1
FR
North America, Illinois, United States, Chicago
Shared Deals: 2
AC
North America, California, United States, Los Angeles
Shared Deals: 2
CS
North America, Washington, United States, Kirkland
Shared Deals: 2
AS
North America, Texas, United States, Austin
Shared Deals: 1

What are some of recent deals done by Zetta Venture Partners?

Cervo AI

New York, New York, United States

AI Automations for Global Trade

Software
SeedJul 29, 2025
Amount Raised: $5,000,000
Pimloc

London, England, United Kingdom

Pimloc's deep learning SaaS platform, Secure Redact, enables public and private organisations to protect personal data in video at scale.

Artificial Intelligence (AI)Big DataEnterprise SoftwareInformation TechnologyMachine LearningPrivacySecuritySoftware
SeedJul 7, 2025
Amount Raised: $5,000,000
EnsoData

Madison, Wisconsin, United States

EnsoData is a healthcare technology company that offers AI-powered software to improve sleep study management and diagnostics.

AnalyticsArtificial Intelligence (AI)Health CareMachine LearningSoftware
Series BJun 25, 2025
Amount Raised: $20,000,000
Gable

Seattle, Washington, United States

Gable is a shift-left data management platform for collaboration to write and execute data contracts.

AnalyticsCollaborationData ManagementInformation TechnologySaaS
Series AMar 31, 2025
Amount Raised: $20,000,000
Workhelix

Palo Alto, California, United States

Workhelix is a developer of workforce management platform to assist with business management.

Artificial Intelligence (AI)Information TechnologySoftware
Series AFeb 27, 2025
Amount Raised: $15,000,000
VideaHealth

Boston, Massachusetts, United States

VideaHealth is offers dentistAI’s software automatically detects pathologies in dental imaging, helping dentists avoid missing diseases.

BiotechnologyHealth CareSoftware
Series BJan 28, 2025
Amount Raised: $40,000,000
Trustero

Palo Alto, California, United States

Trustero provides solutions and services that enable demonstrable, sustainable trustworthiness for emerging enterprises.

ComplianceCyber Security
Series ANov 21, 2024
Amount Raised: $10,350,000
Jimini Health

Stanford, California, United States

Jimini’s mission is to radically improve the efficacy of mental health care across the world.

Artificial Intelligence (AI)Health CareMental HealthWellness
Pre SeedNov 19, 2024
Amount Raised: $8,000,000
Noetik

South San Francisco, California, United States

Noetik is an AI-native biotechnology company.

BiotechnologyLife Science
Series AAug 28, 2024
Amount Raised: $40,000,000
Nabla Bio

Cambridge, Massachusetts, United States

Nabla Bio is an autoverse platform of proprietary biologically informed machine learning that co-develops antibody drugs.

BiopharmaBiotechnologyMachine Learning
Series AMay 14, 2024
Amount Raised: $26,000,000