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25madison

North America, New York, United States, New York

Description

25madison is a New York-based venture platform that operates with a dual approach, functioning as both a venture studio and an early-stage venture capital firm. Established to identify, incubate, and invest in innovative businesses, the firm distinguishes itself by often partnering with large corporations to co-create new ventures or accelerate existing startups. This unique model allows them to leverage corporate resources, market insights, and distribution channels, providing a significant advantage to their portfolio companies beyond just financial capital.

The firm's investment thesis centers on identifying disruptive opportunities across a diverse range of sectors, including but not limited to fintech, health tech, consumer, enterprise software, and real estate technology. 25madison aims to build and scale companies that address significant market needs or capitalize on emerging trends. Their collaborative approach with corporate partners, such as Johnson & Johnson and Apollo Global Management, underscores their strategy of de-risking new ventures and providing a clear path to market for their incubated and invested companies.

For their direct investments, 25madison typically targets early-stage companies, ranging from Seed to Series A and occasionally Series B rounds. Their initial investment, or first check, generally falls within a range of $500,000 to $5,000,000. This range allows them to provide meaningful capital to nascent companies while also participating in larger, more established early-stage rounds. Beyond capital, 25madison provides strategic guidance, operational support, and access to their extensive network, reflecting their commitment to actively supporting the growth of their portfolio.

Overall, 25madison positions itself as more than just a capital provider; it is a strategic partner focused on building and scaling high-potential businesses. Their hybrid model of venture incubation and direct investment, coupled with strong corporate partnerships, enables them to foster innovation and drive significant value creation in the startup ecosystem.

Investor Profile

25madison has backed more than 32 startups, with 4 new investments in the last 12 months alone. The firm has led 4 rounds, about 13% of its total and boasts 3 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Seed, Series A, Pre Seed rounds (top funding stages).
  • Majority of deals are located in United States, Israel.
  • Strong thematic focus on Health Care, Information Technology, Software.
  • Typical check size: $500K – $5M.

Stage Focus

  • Seed (41%)
  • Series A (31%)
  • Pre Seed (16%)
  • Series B (9%)
  • Series Unknown (3%)

Country Focus

  • United States (91%)
  • Israel (6%)

Industry Focus

  • Health Care
  • Information Technology
  • Software
  • Saas
  • Artificial Intelligence (Ai)
  • Machine Learning
  • Food And Beverage
  • Legal
  • Legal Tech
  • Digital Media
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does 25madison frequently co-invest with?

Gaingels
North America, Vermont, United States, Burlington
Co-Investments: 4
Kyber Knight Capital
North America, California, United States, San Francisco
Co-Investments: 2
focal
North America, California, United States, San Francisco
Co-Investments: 2
Plug and Play
North America, California, United States, Sunnyvale
Co-Investments: 4
Afore Capital
North America, California, United States, San Francisco
Co-Investments: 2
Unusual Ventures
North America, California, United States, Menlo Park
Co-Investments: 2
SixThirty
North America, Missouri, United States, St Louis
Co-Investments: 2
WVV Capital
North America, Wisconsin, United States, Milwaukee
Co-Investments: 2
Breyer Capital
North America, California, United States, Menlo Park
Co-Investments: 2
Alumni Ventures
North America, New Hampshire, United States, Manchester
Co-Investments: 3

Which angels does 25madison often collaborate with?

AB
North America, Georgia, United States, Atlanta
Shared Deals: 1
AA
Europe, England, United Kingdom, London
Shared Deals: 1
AM
North America, California, United States, Los Angeles
Shared Deals: 1
AI
North America, California, United States, San Francisco
Shared Deals: 1
AO
North America, California, United States, San Francisco
Shared Deals: 1
CS
Europe, Madrid, Spain, Madrid
Shared Deals: 1
AL
North America, New York, United States, New York
Shared Deals: 1
BG
North America, California, United States, San Francisco
Shared Deals: 1
AM
Europe, England, United Kingdom, London
Shared Deals: 1
AL
North America, Florida, United States, Miami
Shared Deals: 1

What are some of recent deals done by 25madison?

Ovasave

Abu Dhabi, Abu Dhabi, United Arab Emirates

Ovasave is a technology platform that connects women to fertility services.

FertilityHealth CareHospital
Pre SeedJul 17, 2025
Amount Raised: $1,200,000
Handspring Health

Newark, New Jersey, United States

Handspring provides quality and evidence-based mental healthcare for children.

Health CareMental HealthPersonal Health
Series AJun 26, 2025
Amount Raised: $12,000,000

Kouper Health is a healthcare company that uses EHR integration, machine learning, and automation to improve transitions of care.

Electronic Health Record (EHR)Health CareMachine Learning
Series AMay 8, 2025
Amount Raised: $10,000,000
Keragon

Boston, Massachusetts, United States

HIPAA-compliant workflow automation platform.

Health Care
SeedFeb 12, 2025
Amount Raised: $7,500,000
Paxton

Palo Alto, California, United States

Paxton is an innovative legal technology firm transforming the legal landscape.

Artificial Intelligence (AI)LegalLegal Tech
Series AJan 29, 2025
Amount Raised: $22,000,000
Wilya

Mechanicsburg, Pennsylvania, United States

Wilya’s software solution enables manufacturers to digitise frontline skills data and offer flexible schedules to workers

Information TechnologyManufacturingSoftwareSupply Chain Management
SeedJun 24, 2024
Amount Raised: $4,000,000
Keragon

Boston, Massachusetts, United States

HIPAA-compliant workflow automation platform.

Health Care
Pre SeedJun 4, 2024
Amount Raised: $3,000,000
Midi Health

Menlo Park, California, United States

Midi Health is a virtual care clinic for women that treats depression, gynecological cancer, and period problems.

Health CareMedicalTherapeuticsWomen's
Series ASep 27, 2023
Amount Raised: $25,000,000
Paxton AI

Portland, Oregon, United States

Paxton AI is a legal tech company that employs generative AI for precise, comprehensive regulatory insights.

Artificial Intelligence (AI)LegalLegal Tech
SeedSep 19, 2023
Amount Raised: $6,000,000
Croissant

Nashville, Tennessee, United States

Croissant provides Guaranteed Buybacks at Point of Sale and beyond, enabling retailers and consumers to benefit from the resale ecosystem.

Advertising PlatformsInformation TechnologyMobile AppsSalesSoftware
SeedJul 27, 2023
Amount Raised: $24,000,000