Intersouth Partners

Intersouth Partners was a prominent venture capital firm based in Durham, North Carolina, established in 1985. As one of the most active and experienced venture funds in the Southeastern United States, Intersouth played a pivotal role in fostering the region's burgeoning technology and life sciences sectors. The firm primarily focused on early-stage companies, providing crucial capital and strategic guidance to innovative startups looking to scale. Its long-standing presence helped to cultivate a robust entrepreneurial ecosystem across the Southeast.

Over its operational history, Intersouth Partners successfully raised eight distinct venture capital funds, accumulating over $780 million in committed capital. This substantial capital base allowed the firm to invest in a diverse portfolio of more than 100 private companies, contributing significantly to the growth of numerous enterprises from their inception. Their investment thesis centered on identifying high-potential ventures within their target industries, often becoming the first institutional investor.

The firm's final fund, Intersouth Partners VIII, closed in 2007 with $275 million, marking its last significant capital raise for new investments. While Intersouth Partners was a cornerstone of venture funding in the Southeast for decades, it has largely transitioned from actively making new investments. The firm is now primarily focused on managing its existing portfolio companies and realizing returns for its limited partners, effectively winding down its new investment activities. Its legacy, however, continues to influence the regional venture landscape through the successful companies it helped launch and grow.