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Longitude Capital

North America, California, United States, Menlo Park

Description

Longitude Capital is a prominent venture capital firm based in Menlo Park, California, dedicated to investing in transformative biotechnology and medical technology companies. Established with a deep focus on the healthcare sector, the firm primarily targets late-stage venture and growth equity opportunities, though it also engages in select early-stage investments. Their investment strategy centers on identifying companies with compelling scientific platforms, strong management teams, and significant potential to address unmet medical needs or improve patient care. Longitude Capital's expertise spans various therapeutic areas and medical device innovations, reflecting a comprehensive approach to healthcare investment.

The firm has a robust track record of raising substantial capital to support its investment activities. In 2023, Longitude Capital successfully closed its seventh fund, Longitude Capital VII, with a significant commitment of $630 million. This latest fund underscores the firm's continued ability to attract capital from a diverse base of limited partners, including endowments, foundations, and institutional investors. The consistent growth in their fund sizes over the years demonstrates investor confidence in their specialized investment thesis and their team's ability to generate returns within the complex healthcare landscape.

Longitude Capital's investment philosophy emphasizes providing significant capital and strategic guidance to its portfolio companies. They often act as lead or co-lead investors in financing rounds, enabling companies to advance clinical trials, scale manufacturing, and bring innovative products to market. With total capital raised across all its funds now exceeding $2.5 billion, Longitude Capital possesses substantial resources to support its portfolio companies through various stages of development, from initial investment through to potential public offerings or strategic acquisitions. Their long-term perspective and deep industry networks are crucial assets for the companies they back, helping to navigate regulatory pathways and commercialization challenges inherent in the biotech and medtech sectors.

Investor Profile

Longitude Capital has backed more than 122 startups, with 11 new investments in the last 12 months alone. The firm has led 43 rounds, about 35% of its total and boasts 36 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series B, Series C, Series A rounds (top funding stages).
  • Majority of deals are located in United States, Canada, Ireland.
  • Strong thematic focus on Health Care, Biotechnology, Medical.
  • Led 3 rounds in the past year.
  • Typical check size: $10M – $40M.

Stage Focus

  • Series B (24%)
  • Series C (20%)
  • Series A (18%)
  • Series D (10%)
  • Series Unknown (9%)
  • Post Ipo Equity (6%)
  • Private Equity (5%)
  • Series E (3%)
  • Debt Financing (2%)
  • Series F (2%)

Country Focus

  • United States (90%)
  • Canada (4%)
  • Ireland (2%)
  • Switzerland (2%)
  • France (1%)
  • United Kingdom (1%)

Industry Focus

  • Health Care
  • Biotechnology
  • Medical
  • Therapeutics
  • Pharmaceutical
  • Medical Device
  • Biopharma
  • Health Diagnostics
  • Manufacturing
  • Life Science
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does Longitude Capital frequently co-invest with?

OrbiMed
North America, New York, United States, New York
Co-Investments: 15
Sofinnova Investments
North America, California, United States, Menlo Park
Co-Investments: 7
Wellington Management
North America, Massachusetts, United States, Boston
Co-Investments: 7
Omega Funds
Europe, Geneve, Switzerland, Geneva
Co-Investments: 11
Kleiner Perkins
North America, California, United States, Menlo Park
Co-Investments: 8
New Enterprise Associates
North America, California, United States, Menlo Park
Co-Investments: 7
RA Capital Management
North America, Massachusetts, United States, Boston
Co-Investments: 20
Frazier Healthcare Partners
North America, Washington, United States, Seattle
Co-Investments: 11
Rock Springs Capital
North America, Maryland, United States, Baltimore
Co-Investments: 8
Vivo Capital
North America, California, United States, Palo Alto
Co-Investments: 7

Which angels does Longitude Capital often collaborate with?

AB
North America, Tennessee, United States, Nashville
Shared Deals: 1
EM
North America, California, United States, Redwood City
Shared Deals: 1

What are some of recent deals done by Longitude Capital?

Cohere Health

Boston, Massachusetts, United States

Cohere Health is a SaaS company that focuses on improving the efficiency and effectiveness of healthcare delivery.

Consumer SoftwareHealth CareSaaSSoftware
Series CMay 14, 2025
Amount Raised: $90,000,000
CytomX Therapeutics

South San Francisco, California, United States

CytomX Therapeutics is a biotechnology company that focuses on developing proteolytically-activated antibodies.

BiotechnologyHealth CarePharmaceuticalTherapeutics
Post Ipo EquityMay 12, 2025
Amount Raised: $100,000,000
MicroTransponder

Dallas, Texas, United States

MicroTransponder is a medical device company that develops and commercializes neurostimulation devices to treat neurological diseases.

Health CareMedicalMedical Device
Series FMar 12, 2025
Amount Raised: $65,000,000
Helicore Biopharma

San Mateo, California, United States

Helicore Biopharma is a biopharmaceutical company that discovers and develops novel weight-loss therapeutics.

BiopharmaBiotechnologyHealth CareMedicalTherapeutics
Series AJan 28, 2025
Amount Raised: $65,000,000
Aviceda Therapeutics

Cambridge, Massachusetts, United States

Aviceda Therapeutics is a late-stage pre-clinical biotech company developing drugs for treating glyco-immune diseases.

BiotechnologyHealth CareLife SciencePharmaceuticalTherapeutics
Series CJan 7, 2025
Amount Raised: $207,500,000
FIRE1

Dublin, Dublin, Ireland

FIRE1 and is based in Dublin, Ireland, will focus on developing novel therapeutic devices.

BiotechnologyHealth CareMedical DeviceTherapeutics
Series UnknownJan 7, 2025
Amount Raised: $120,000,000
VeraDermics

New Haven, Connecticut, United States

VeraDermics is a dermatology company that creates novel drug delivery mechanisms for a pain-free cure for skin conditions such as warts.

Health CarePharmaceuticalTherapeutics
Series BDec 11, 2024
Amount Raised: $75,000,000
Alentis Therapeutics

Allschwil, Basel-Landschaft, Switzerland

ALENTIS Therapeutics is a Swiss-French biotech company developing novel therapeutics in advanced liver disease and cancer.

BiotechnologyManufacturingPharmaceuticalTherapeutics
Series DNov 12, 2024
Amount Raised: $181,400,000
Alpha9 Theranostics

Vancouver, British Columbia, Canada

Alpha9 Theranostics is a biopharma company that focuses on radiotherapeutics for the treatment of solid and hematologic malignancies.

BiotechnologyMedicalProduct Research
Series COct 23, 2024
Amount Raised: $175,000,000
OrsoBio

Palo Alto, California, United States

OrsoBio is a clinical-stage biopharmaceutical company that develops therapies to treat severe metabolic disorders.

BiopharmaBiotechnologyHealth CareMedicalTherapeutics
Series BSep 6, 2024
Amount Raised: $67,000,000