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Mission BioCapital

North America, Massachusetts, United States, Cambridge

Description

Mission BioCapital is a prominent venture capital firm dedicated to investing in transformative early-stage life science companies. With dual headquarters in Cambridge, Massachusetts, and San Francisco, California, the firm strategically positions itself within two of the world's leading biotech innovation hubs. Their investment philosophy centers on identifying and nurturing groundbreaking scientific discoveries across various sectors of the life sciences, aiming to translate them into commercially viable solutions that address significant unmet medical needs.

The firm's investment strategy is highly focused on seed and early-stage opportunities, encompassing a broad spectrum of life science innovations. Mission BioCapital actively seeks out companies developing novel therapeutics, advanced diagnostics, innovative medical devices, and essential research tools. They pride themselves on bringing deep scientific expertise and operational experience to their portfolio companies, often working closely with founders to navigate the complex landscape of drug development and commercialization. A significant milestone for the firm was the closing of Mission BioCapital Fund IV in October 2021, which secured $275 million in commitments, underscoring their continued growth and commitment to the sector.

This latest fund builds upon a strong foundation established by previous vehicles, including their predecessor, Fund III, which closed at $150 million in 2018. The increase in fund size reflects the firm's expanding capacity to support capital-intensive biotech ventures and to participate meaningfully in subsequent funding rounds for their portfolio companies. Mission BioCapital typically acts as a lead or significant co-investor in Seed and Series A rounds, providing the crucial early capital necessary for companies to achieve key scientific and preclinical milestones. Their robust capital base allows them to support companies through multiple stages of development, from initial concept to clinical trials and beyond.

Mission BioCapital's long-term vision is to foster the creation of companies that will redefine healthcare and improve human well-being. By combining financial investment with strategic guidance and a vast network of industry experts, the firm plays a pivotal role in accelerating the development of cutting-edge biotechnologies. Their consistent fundraising success and specialized focus solidify their position as a key player in the early-stage life science venture ecosystem, contributing significantly to the advancement of medical innovation.

Investor Profile

Mission BioCapital has backed more than 76 startups, with 15 new investments in the last 12 months alone. The firm has led 13 rounds, about 17% of its total and boasts 17 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series A, Series B, Series Unknown rounds (top funding stages).
  • Majority of deals are located in United States, Switzerland, Germany.
  • Strong thematic focus on Biotechnology, Health Care, Therapeutics.
  • Led 10 rounds in the past year.
  • Typical check size: $2M – $10M.

Stage Focus

  • Series A (25%)
  • Series B (25%)
  • Series Unknown (24%)
  • Seed (11%)
  • Series C (7%)
  • Pre Seed (7%)
  • Series E (1%)
  • Series D (1%)

Country Focus

  • United States (96%)
  • Switzerland (3%)
  • Germany (1%)

Industry Focus

  • Biotechnology
  • Health Care
  • Therapeutics
  • Medical
  • Life Science
  • Pharmaceutical
  • Genetics
  • Precision Medicine
  • Biopharma
  • Machine Learning
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does Mission BioCapital frequently co-invest with?

OrbiMed
North America, New York, United States, New York
Co-Investments: 4
Amgen Ventures
North America, California, United States, San Francisco
Co-Investments: 4
Pfizer Venture Investments
North America, New York, United States, New York
Co-Investments: 6
Alexandria Venture Investments
North America, California, United States, Pasadena
Co-Investments: 7
Mission Bay Capital
North America, California, United States, San Francisco
Co-Investments: 7
RA Capital Management
North America, Massachusetts, United States, Boston
Co-Investments: 6
Novo Holdings
Europe, Hovedstaden, Denmark, Hellerup
Co-Investments: 5
Polaris Partners
North America, Massachusetts, United States, Boston
Co-Investments: 4
AbbVie Biotech Ventures
North America, Illinois, United States, North Chicago
Co-Investments: 4
Inkef
Europe, Noord-Holland, The Netherlands, Amsterdam
Co-Investments: 4

Which angels does Mission BioCapital often collaborate with?

LW
North America, Washington, United States, Seattle
Shared Deals: 2
SH
North America, New York, United States, New York
Shared Deals: 1
AP
North America, California, United States, Los Angeles
Shared Deals: 1
MS
North America, California, United States, Santa Monica
Shared Deals: 1
VP
North America, New York, United States, New York
Shared Deals: 1
Stephen Thompson
Oceania, Victoria, Australia, Melbourne
Shared Deals: 1
JR
North America, California, United States, San Francisco
Shared Deals: 1
AI
Europe, Cyprus
Shared Deals: 1
JM
North America, Massachusetts, United States, Cambridge
Shared Deals: 1

What are some of recent deals done by Mission BioCapital?

D2B3

New Haven, Connecticut, United States

D2B3is a pre-clinical biotechnology startup dedicated to creating innovative drug delivery technologies for the brain.

Biotechnology
Pre SeedApr 7, 2025
Amount Raised: $500,000
SiteOne Therapeutics

South San Francisco, California, United States

SiteOne Therapeutics is a biopharmaceutical company that develops pain therapeutics to treat sensory disorders.

BiotechnologyHealth DiagnosticsMedicalTherapeutics
Series CDec 18, 2024
Amount Raised: $100,000,000
Alessa Therapeutics

San Francisco, California, United States

Alessa Therapeutics develops localized treatments for solid organ disease.

BiotechnologyHealth CareTherapeutics
SeedDec 12, 2024
Amount Raised: $15,000,000
Nuvig Therapeutics

Redwood City, California, United States

Nuvig Therapeutics is a biotechnology company developing therapies to induce natural mechanisms to restore immune homeostasis.

BiotechnologyHealth CareTherapeutics
Series BDec 5, 2024
Amount Raised: $161,000,000
Jupiter BioVentures

Delaware City, Delaware, United States

Jupiter BioVentures is a creation engine company that focuses on de-risking early-stage projects.

BiotechnologyTherapeutics
Series UnknownNov 19, 2024
Amount Raised: $70,000,000
Bullseye Biosciences

Allston, Massachusetts, United States

Bullseye Biosciences is a biotechnology company that offers drug discovery services.

Artificial Intelligence (AI)BiopharmaBiotechnology
Pre SeedOct 30, 2024
Babylon Biosciences

San Francisco, California, United States

Babylon Biosciences is focused on discovering and developing small-molecule therapeutics to treat Alzheimer's disease.

Biotechnology
Pre SeedOct 30, 2024
Cloverleaf Bio

New Haven, Connecticut, United States

Cloverleaf Bio develops an RNA therapeutic platform for oncology.

BiotechnologyGeneticsManufacturing
Pre SeedOct 30, 2024
NuCyRNA Therapeutics

Boston, Massachusetts, United States

NuCyRNA Therapeuticsis a RNA-targeting therapeutics based on a novel oligonucleotide platform, with an initial focus on CNS diseases.

Biotechnology
SeedOct 30, 2024
Velocity Bio

San Carlos, California, United States

Velocity Bio is a Stanford University spinout developing high-throughput platforms capable of selectivity-first allosteric drug discovery.

BiotechnologyLife ScienceProduct Research
SeedOct 30, 2024