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MRL Ventures Fund

North America, Massachusetts, United States, Cambridge

Description

MRL Ventures Fund is the independent early-stage therapeutics venture capital fund of Merck & Co., Inc., established in 2012. Operating with strategic autonomy, its primary mission is to identify, invest in, and nurture groundbreaking science with the potential to transform patient care. The fund focuses exclusively on innovative therapeutic companies, aiming to address significant unmet medical needs across a broad spectrum of disease areas, including oncology, neuroscience, infectious diseases, and immunology. Its investment thesis centers on novel biological insights and platforms that can lead to the development of first-in-class or best-in-class medicines.

MRL Ventures Fund primarily targets Seed, Series A, and occasionally Series B rounds, seeking to partner with visionary founders and scientific teams. The fund is known for its deep scientific diligence and its commitment to providing more than just capital. Portfolio companies benefit from strategic guidance, operational support, and, where appropriate, access to the vast scientific and R&D expertise within the broader Merck ecosystem, while maintaining their independence.

Financially, MRL Ventures Fund has demonstrated a significant commitment to early-stage biotech. The initial fund launched in 2012, and a second fund, MRL Ventures Fund II, was announced in 2019 with $150 million in capital, bringing their total capital under management to $250 million across both funds. Typical initial investments from MRL Ventures Fund range from $1 million to $10 million, often taking a lead or co-lead position in early funding rounds. This approach allows them to be a foundational partner for emerging therapeutic companies, helping them de-risk their science and accelerate their path to clinical development.

Investor Profile

MRL Ventures Fund has backed more than 49 startups, with 5 new investments in the last 12 months alone. The firm has led 8 rounds, about 16% of its total and boasts 13 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series A, Series B, Series C rounds (top funding stages).
  • Majority of deals are located in United States, The Netherlands, Belgium.
  • Strong thematic focus on Biotechnology, Therapeutics, Health Care.
  • Led 2 rounds in the past year.
  • Typical check size: $1M – $10M.

Stage Focus

  • Series A (41%)
  • Series B (24%)
  • Series C (20%)
  • Seed (6%)
  • Series D (2%)
  • Series E (2%)
  • Series Unknown (2%)
  • Corporate Round (2%)

Country Focus

  • United States (92%)
  • The Netherlands (6%)
  • Belgium (2%)

Industry Focus

  • Biotechnology
  • Therapeutics
  • Health Care
  • Medical
  • Life Science
  • Genetics
  • Oncology
  • Medical Device
  • Biopharma
  • Emergency Medicine
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does MRL Ventures Fund frequently co-invest with?

Solasta Ventures
North America, Massachusetts, United States, Boston
Co-Investments: 6
Amgen Ventures
North America, California, United States, San Francisco
Co-Investments: 7
Omega Funds
Europe, Geneve, Switzerland, Geneva
Co-Investments: 7
SV Health Investors
North America, Massachusetts, United States, Boston
Co-Investments: 9
Alexandria Venture Investments
North America, California, United States, Pasadena
Co-Investments: 5
Agent Capital
North America, Massachusetts, United States, Cambridge
Co-Investments: 6
Google Ventures
North America, California, United States, Mountain View
Co-Investments: 7
Atlas Venture
North America, Massachusetts, United States, Cambridge
Co-Investments: 8
Dementia Discovery Fund
Europe, England, United Kingdom, London
Co-Investments: 7
AbbVie Biotech Ventures
North America, Illinois, United States, North Chicago
Co-Investments: 7

Which angels does MRL Ventures Fund often collaborate with?

RK
North America, California, United States
Shared Deals: 1

What are some of recent deals done by MRL Ventures Fund?

Therini Bio

San Francisco, California, United States

Therini Bio specializes in fibrin-targeting therapies to treat inflammatory neurological and retinal diseases.

BiotechnologyHealth CareMedicalTherapeutics
Series AMay 14, 2025
Amount Raised: $39,000,000
PAQ Therapeutics

Cambridge, Massachusetts, United States

PAQ Therapeutics is a biotechnology company pioneering a new approach to restoring health and curing disease through autophagy.

BiotechnologyHealth CareTherapeutics
Series BMay 5, 2025
Amount Raised: $39,000,000
ATB Therapeutics

Aye, Luxembourg, Belgium

ATB Therapeutics is a biopharmaceutical company that provides novel therapeutic solutions and treatments for cancer patients.

BiotechnologyHealth CareTherapeutics
Series ANov 18, 2024
Amount Raised: $57,210,541
Axonis Therapeutics

Boston, Massachusetts, United States

Axonis Therapeutics is a neuro-focused biotechnology company that focuses on the development of novel neuromedicines.

BiotechnologyLife ScienceMedical
Series AOct 30, 2024
Amount Raised: $115,000,000
Aktis Oncology

Boston, Massachusetts, United States

Aktis Oncology is a biotechnology company that designs and develops novel class radiopharmaceuticals.

BiotechnologyHealth CareLife ScienceOncology
Series BSep 30, 2024
Amount Raised: $175,000,000
InduPro

Seattle, Washington, United States

InduPro is a biotechnology company that specializes in protein therapeutics and cell-surface platform technologies.

BiotechnologyMedicalTherapeutics
Series AJun 13, 2024
Amount Raised: $85,000,000
Insamo

Berkeley, California, United States

Insamo offers the discovery of membrane-permeable & orally available cyclic-peptides at an unprecedented scale.

BiotechnologyLife SciencePharmaceutical
SeedFeb 21, 2024
Amount Raised: $12,000,000
Eyebiotech

New York, New York, United States

Eyebiotech is an ophthalmology biotechnology company that specializes in therapies for eye diseases.

BiotechnologyMedical
Series ANov 14, 2023
Amount Raised: $65,000,000
VectorY

Amsterdam, Noord-Holland, The Netherlands

VectorY is an integrated gene therapy company focused on development of therapeutics for CNS, somatic disorders and muscle diseases.

Biotechnology
Series ANov 13, 2023
Amount Raised: $138,046,904
Ray Therapeutics

San Diego, California, United States

Ray Therapeutics is a biotech company that develops optogenetic gene therapies for patients with blinding diseases.

BiotechnologyHealth CareTherapeutics
Series AMay 16, 2023
Amount Raised: $100,000,000