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U.S. Venture Partners

North America, California, United States, Menlo Park

Description

U.S. Venture Partners (USVP), established in 1981, is a long-standing venture capital firm based in Menlo Park, California, renowned for its focus on early-stage investments. The firm primarily targets opportunities within the information technology and healthcare sectors, encompassing a broad range of sub-segments. With a history spanning over four decades, USVP has built a significant presence in the venture landscape, known for identifying and nurturing innovative companies from their foundational stages.

USVP's investment strategy is centered on identifying and partnering with disruptive companies at their foundational stages, typically from Seed through Series B rounds. Within information technology, their interests span enterprise software, SaaS, cloud infrastructure, cybersecurity, data & AI, and fintech. In healthcare, they actively invest in digital health, healthcare IT, biotechnology, and medtech innovations. The firm prides itself on being a first institutional investor or an early strategic partner, providing not just capital but also operational guidance and network access to its portfolio companies.

With a robust financial foundation, USVP has raised significant capital, with its total assets under management (AUM) exceeding $4.1 billion across 14 funds. Their most recent fund, USVP XIV, closed in 2022 with $350 million, underscoring their continued commitment to early-stage venture investing. While specific initial check sizes can vary based on the stage and needs of the company, USVP typically deploys first checks ranging from approximately $1 million for Seed rounds up to $20 million for leading Series B investments. The firm has a strong track record, having made over 600 investments and achieved more than 170 exits, including numerous IPOs and M&A transactions.

Investor Profile

U.S. Venture Partners has backed more than 591 startups, with 14 new investments in the last 12 months alone. The firm has led 182 rounds, about 31% of its total and boasts 158 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series B, Series A, Series C rounds (top funding stages).
  • Majority of deals are located in United States, Israel, Canada.
  • Strong thematic focus on Software, Health Care, Enterprise Software.
  • Led 7 rounds in the past year.
  • Typical check size: $1M – $20M.

Stage Focus

  • Series B (27%)
  • Series A (20%)
  • Series C (19%)
  • Series Unknown (16%)
  • Series D (9%)
  • Series E (4%)
  • Series F (2%)
  • Seed (1%)
  • Post Ipo Equity (1%)
  • Private Equity (1%)

Country Focus

  • United States (94%)
  • Israel (4%)
  • Canada (1%)
  • Pakistan (1%)

Industry Focus

  • Software
  • Health Care
  • Enterprise Software
  • Manufacturing
  • Medical
  • Biotechnology
  • Information Technology
  • Medical Device
  • Internet
  • Mobile
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does U.S. Venture Partners frequently co-invest with?

First Round Capital
North America, California, United States, San Francisco
Co-Investments: 13
Mayfield Fund
North America, California, United States, Menlo Park
Co-Investments: 25
New Enterprise Associates
North America, California, United States, Menlo Park
Co-Investments: 35
Norwest Venture Partners
North America, California, United States, Palo Alto
Co-Investments: 18
Versant Ventures
North America, California, United States, Menlo Park
Co-Investments: 15
Battery Ventures
North America, Massachusetts, United States, Boston
Co-Investments: 18
OUP (Osage University Partners)
North America, Pennsylvania, United States, Bala Cynwyd
Co-Investments: 16
Morgenthaler Ventures
North America, California, United States, Menlo Park
Co-Investments: 26
Venrock
North America, California, United States, Palo Alto
Co-Investments: 57
The Vertical Group
North America, New Jersey, United States, Basking Ridge
Co-Investments: 18

Which angels does U.S. Venture Partners often collaborate with?

Gur Shatz
Asia, Tel Aviv, Israel, Tel Aviv
Shared Deals: 2
CJ
North America, Illinois, United States, Chicago
Shared Deals: 2
VD
North America, District of Columbia, United States, Washington
Shared Deals: 1
BC
North America, Illinois, United States, Chicago
Shared Deals: 2
Dave Duffield
North America, United States
Shared Deals: 2
Shared Deals: 2
AW
North America, Florida, United States, Naples
Shared Deals: 1
TC
North America, California, United States, San Francisco
Shared Deals: 2
SM
North America, New York, United States, New York
Shared Deals: 2
Shlomo Kramer
Asia, Tel Aviv, Israel, Tel Aviv
Shared Deals: 4

What are some of recent deals done by U.S. Venture Partners?

Neuros Medical

Willoughby, Ohio, United States

Neuros Medical develops neurostimulation therapies for patients suffering with unmet medical needs.

Health CareLife ScienceMedicalMedical DeviceTherapeutics
Series DJul 9, 2025
Amount Raised: $56,000,000
Clarify AI

Plymouth, Michigan, United States

Clarify is an AI-powered writing tool that accelerates the academic writing process.

Artificial Intelligence (AI)EducationGenerative AIHigher Education
Series AJun 25, 2025
Amount Raised: $15,000,000
Clarify

Seattle, Washington, United States

Clarify offers a CRM that assists in managing sales processes.

Artificial Intelligence (AI)CRMSaaS
Series UnknownJun 25, 2025
Amount Raised: $14,999,998
Zero Networks

Tel Aviv, Tel Aviv, Israel

Zero Networks automates the development and enforcement of network access rules throughout an entire network.

Cyber SecurityData Center AutomationInformation TechnologyNetwork Security
Series CJun 3, 2025
Amount Raised: $55,000,000
Heartflow

Mountain View, California, United States

Heartflow is a medical technology company that provides various methods of diagnosis and treatment of cardiovascular disease.

Artificial Intelligence (AI)BiotechnologyHealth CareHealth DiagnosticsMedical
Convertible NoteMar 26, 2025
Amount Raised: $98,000,000
MicroTransponder

Dallas, Texas, United States

MicroTransponder is a medical device company that develops and commercializes neurostimulation devices to treat neurological diseases.

Health CareMedicalMedical Device
Series FMar 12, 2025
Amount Raised: $65,000,000
Shoulder Innovations

Holland, Michigan, United States

Shoulder Innovations is a medical device company that develops inset glenoid fixation technology.

BiotechnologyHealth CareMedical Device
Series EMar 10, 2025
Amount Raised: $40,000,000
Nervonik

Los Angeles, California, United States

Nervonik is a medical device company developing an opioid-free peripheral nerve stimulation (PNS) system.

ManufacturingMedicalMedical Device
Series AMar 4, 2025
Amount Raised: $13,000,000
Delfina

San Francisco, California, United States

Delfina provides a personalized prenatal care system that uses the power of data to keep moms and babies safe during pregnancy.

Health CareMedicalPersonal HealthService IndustryWellness
Series AJan 28, 2025
Amount Raised: $17,000,000
Quantifind

Palo Alto, California, United States

Quantifind is a risk intelligence company that offers AI solutions for emerging threat detection and watchlist screening.

AnalyticsArtificial Intelligence (AI)Big DataFinTechSoftware
Series UnknownJan 16, 2025
Amount Raised: $22,000,000