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OUP (Osage University Partners)

North America, Pennsylvania, United States, Bala Cynwyd

Description

Osage University Partners (OUP) is a distinctive venture capital firm based in Bala Cynwyd, United States, specializing in the commercialization of university research. Unlike traditional VC firms, OUP operates with a unique model, partnering directly with leading academic institutions to identify and invest in promising startups emerging from their research labs. This strategic alignment allows OUP to access a proprietary deal flow of cutting-edge technologies and scientific breakthroughs with significant market potential. Their mission is to bridge the gap between groundbreaking academic innovation and successful commercial ventures.

OUP's investment strategy is deeply rooted in collaboration with its extensive network of academic partners. The firm has established relationships with over 100 universities, including top-tier research institutions across the United States. Through these partnerships, OUP gains early insight into nascent technologies, allowing them to invest in companies at various stages, primarily Seed, Series A, and Series B. They often co-invest alongside other prominent venture capital firms, providing not only capital but also strategic guidance, industry connections, and operational support to help these university spinouts scale and achieve market traction.

With a robust track record, OUP has demonstrated its commitment to fostering innovation from the academic world. The firm has successfully raised multiple funds, including its most recent OUP IV, which closed with $300 million in capital, bringing their total assets under management to approximately $870 million across four funds. This substantial capital base enables OUP to make meaningful investments, with typical first checks ranging from $500,000 for early-stage seed rounds to $5,000,000 for more developed Series A or B opportunities. To date, OUP has invested in over 150 companies, spanning diverse sectors such as life sciences, deep tech, and enterprise software, all originating from university intellectual property.

Investor Profile

OUP (Osage University Partners) has backed more than 219 startups, with 9 new investments in the last 12 months alone. The firm has led 12 rounds, about 5% of its total and boasts 56 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series A, Series B, Series C rounds (top funding stages).
  • Majority of deals are located in United States, United Kingdom, India.
  • Strong thematic focus on Biotechnology, Health Care, Therapeutics.
  • Led 2 rounds in the past year.
  • Typical check size: $500K – $5M.

Stage Focus

  • Series A (35%)
  • Series B (25%)
  • Series C (14%)
  • Series Unknown (8%)
  • Series D (6%)
  • Seed (5%)
  • Post Ipo Equity (2%)
  • Series E (2%)

Country Focus

  • United States (96%)
  • United Kingdom (1%)

Industry Focus

  • Biotechnology
  • Health Care
  • Therapeutics
  • Medical
  • Pharmaceutical
  • Biopharma
  • Medical Device
  • Manufacturing
  • Software
  • Artificial Intelligence (Ai)
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does OUP (Osage University Partners) frequently co-invest with?

OrbiMed
North America, New York, United States, New York
Co-Investments: 25
Sofinnova Investments
North America, California, United States, Menlo Park
Co-Investments: 11
Pfizer Venture Investments
North America, New York, United States, New York
Co-Investments: 11
Alexandria Venture Investments
North America, California, United States, Pasadena
Co-Investments: 12
5AM Ventures
North America, California, United States, Menlo Park
Co-Investments: 13
New Enterprise Associates
North America, California, United States, Menlo Park
Co-Investments: 14
RA Capital Management
North America, Massachusetts, United States, Boston
Co-Investments: 14
U.S. Venture Partners
North America, California, United States, Menlo Park
Co-Investments: 16
The Column Group
North America, California, United States, San Francisco
Co-Investments: 13
ARCH Venture Partners
North America, Illinois, United States, Chicago
Co-Investments: 14

Which angels does OUP (Osage University Partners) often collaborate with?

PK
North America, Tennessee, United States, Nashville
Shared Deals: 2
BD
North America, Kentucky, United States, Louisville
Shared Deals: 2
KF
North America, Texas, United States, Houston
Shared Deals: 2
Shared Deals: 2
HT
Europe, Noord-Brabant, The Netherlands, Tilburg
Shared Deals: 2
Shared Deals: 2
TF
North America, Texas, United States, Dallas
Shared Deals: 2
BG
North America, Washington, United States, Seattle
Shared Deals: 3
GB
Europe, England, United Kingdom, London
Shared Deals: 2
DR
North America, Texas, United States, Houston
Shared Deals: 2

What are some of recent deals done by OUP (Osage University Partners)?

Neuros Medical

Willoughby, Ohio, United States

Neuros Medical develops neurostimulation therapies for patients suffering with unmet medical needs.

Health CareLife ScienceMedicalMedical DeviceTherapeutics
Series DJul 9, 2025
Amount Raised: $56,000,000
University of Puerto Rico-Bayamon

Puerto Rico, Misiones, Argentina

University of Puerto Rico-Bayamon

Higher Education
GrantJun 17, 2025
Amount Raised: $2,300,000
AssetWatch

Westerville, Ohio, United States

AssetWatch is a deployable, remote, end-to-end condition monitoring solution providing predictive insight to enable proactive maintenance.

Big DataIndustrial AutomationInternet of ThingsMachine LearningPredictive Analytics
Series CApr 30, 2025
Amount Raised: $75,000,000

Virtue AI operates as an AI security and compliance platform for applications.

Artificial Intelligence (AI)Information TechnologySoftware
Series AApr 15, 2025
Amount Raised: $30,000,000

Virtue AI operates as an AI security and compliance platform for applications.

Artificial Intelligence (AI)Information TechnologySoftware
SeedApr 15, 2025
Atsena Therapeutics

Durham, North Carolina, United States

Atsena Therapeutics is a clinical-stage gene therapy company that develops novel treatments for inherited forms of blindness.

BiotechnologyHealth CareTherapeutics
Series CApr 2, 2025
Amount Raised: $150,000,000
MicroTransponder

Dallas, Texas, United States

MicroTransponder is a medical device company that develops and commercializes neurostimulation devices to treat neurological diseases.

Health CareMedicalMedical Device
Series FMar 12, 2025
Amount Raised: $65,000,000
Overland AI

Seattle, Washington, United States

Overland AI is a manufacturer and developer of autonomous navigation for off-road autonomous vehicles.

Artificial Intelligence (AI)Autonomous VehiclesMachine LearningRoboticsSoftware
Series AJan 13, 2025
Amount Raised: $32,000,000
VeraDermics

New Haven, Connecticut, United States

VeraDermics is a dermatology company that creates novel drug delivery mechanisms for a pain-free cure for skin conditions such as warts.

Health CarePharmaceuticalTherapeutics
Series BDec 11, 2024
Amount Raised: $75,000,000
Xscape Photonics

New York, New York, United States

Xscape Photonics provides photonic chips for high-speed connections in high-performance computing systems and data centers.

Artificial Intelligence (AI)Data CenterInformation TechnologySemiconductorSimulation
Series AOct 15, 2024
Amount Raised: $44,000,000