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.406 Ventures

North America, Massachusetts, United States, Boston

Description

.406 Ventures is a prominent Boston-based venture capital firm specializing in early-stage technology companies. Founded with a focus on enterprise software, data & cloud, cybersecurity, and healthcare IT, the firm targets disruptive innovations that address significant market needs. They primarily invest in Seed, Series A, and Series B rounds, often taking a lead or co-lead position, and are known for their hands-on approach in supporting portfolio companies.

The firm's investment strategy emphasizes partnering with exceptional management teams building scalable businesses. .406 Ventures provides more than just capital; they offer strategic guidance, operational expertise, and access to a robust network of industry leaders and potential customers. Their deep sector knowledge allows them to identify promising startups and help them navigate the complexities of growth, from product development to market expansion.

Since its inception, .406 Ventures has demonstrated a strong track record of fundraising and successful investments. They have raised over $1 billion in committed capital across five core funds, with their most recent fund, .406 Ventures V, closing at $270 million in 2021. This substantial capital base enables them to make meaningful initial investments and provide follow-on funding as companies mature. The firm's portfolio includes a diverse range of companies that have achieved significant milestones, including successful exits and continued growth, solidifying their reputation as a key player in the venture capital landscape.

Investor Profile

.406 Ventures has backed more than 176 startups, with 5 new investments in the last 12 months alone. The firm has led 50 rounds, about 28% of its total and boasts 34 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series A, Series B, Series C rounds (top funding stages).
  • Majority of deals are located in United States, United Kingdom.
  • Strong thematic focus on Software, Health Care, Cyber Security.
  • Led 2 rounds in the past year.
  • Typical check size: $5M – $20M.

Stage Focus

  • Series A (26%)
  • Series B (23%)
  • Series C (15%)
  • Seed (11%)
  • Series D (10%)
  • Series Unknown (9%)
  • Series E (3%)
  • Series F (2%)
  • Debt Financing (1%)

Country Focus

  • United States (99%)
  • United Kingdom (1%)

Industry Focus

  • Software
  • Health Care
  • Cyber Security
  • Analytics
  • Saas
  • Security
  • Information Technology
  • Artificial Intelligence (Ai)
  • Data Integration
  • Network Security
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does .406 Ventures frequently co-invest with?

Accomplice
North America, Massachusetts, United States, Cambridge
Co-Investments: 10
The Blue Venture Fund
North America, Illinois, United States, Chicago
Co-Investments: 8
Atlas Venture
North America, Massachusetts, United States, Cambridge
Co-Investments: 10
Optum Ventures
North America, Massachusetts, United States, Boston
Co-Investments: 9
F-Prime Capital
North America, Massachusetts, United States, Cambridge
Co-Investments: 16
Polaris Partners
North America, Massachusetts, United States, Boston
Co-Investments: 17
Sandbox Industries
North America, Illinois, United States, Chicago
Co-Investments: 7
RRE Ventures
North America, New York, United States, New York
Co-Investments: 14
Founders Fund
North America, California, United States, San Francisco
Co-Investments: 7
Prism Venture Management
North America, Massachusetts, United States, Needham
Co-Investments: 7

Which angels does .406 Ventures often collaborate with?

JE
North America, Massachusetts, United States, Boston
Shared Deals: 2
Cyrus Massoumi
North America, New York, United States, New York
Shared Deals: 1
Marcos Galperin
South America, Distrito Federal, Argentina, Buenos Aires
Shared Deals: 2
SB
North America, California, United States, Los Angeles
Shared Deals: 2
JK
North America, New Jersey, United States, Livingston
Shared Deals: 2
MB
North America, California, United States, San Francisco
Shared Deals: 3
AB
North America, Tennessee, United States, Nashville
Shared Deals: 2
KC
North America, New York, United States, New York
Shared Deals: 3
SP
North America, Connecticut, United States, Southport
Shared Deals: 1
JK
North America, New York, United States, New York
Shared Deals: 5

What are some of recent deals done by .406 Ventures?

Bluebird Kids Health

Boston, Massachusetts, United States

Bluebird Kids Health delivers superior treatment to help every kid grow.

Health CareHospital
Series AMar 4, 2025
Amount Raised: $31,500,000
Rad Security

San Francisco, California, United States

The Future of Security: AI-Driven, Real-Time Defense

Event ManagementInformation TechnologyIT InfrastructureSaaS
Series AFeb 24, 2025
Amount Raised: $14,000,000
Lynx

Boston, Massachusetts, United States

Lynx provides an API-driven platform for businesses to integrate healthcare financial services, payments, banking, and investments.

FinTechHealth CarePayments
Series AFeb 6, 2025
Amount Raised: $27,000,000
Mindgard

London, England, United Kingdom

Mindgard empowers enterprise security teams to deploy AI and GenAI securely.

Artificial Intelligence (AI)Cyber Security
Series UnknownDec 20, 2024
Amount Raised: $8,169,852
Nema Health

New York, New York, United States

Nema provides comprehensive trauma care administered by PTSD-trained therapists.

Health CareMental HealthPersonal Health
Series ANov 1, 2024
Amount Raised: $14,500,000
Heartbeat Health

New York, New York, United States

Heartbeat Health is a digital health company that utilizes technology to improve cardiovascular disease prevention and management.

Health CareHealth DiagnosticsMedicalmHealthTelehealth
Series CJul 9, 2024
Amount Raised: $24,999,997
Humata Health

Winter Park, Florida, United States

Humata Health is an AI-enabled deep clinical integration that creates prior authorizations for payers and providers using AI and automation.

Artificial Intelligence (AI)
Series AJun 20, 2024
Amount Raised: $25,000,000
Nomad Health

New York, New York, United States

Nomad Health is an online staffing marketplace that connects clinicians to healthcare jobs.

Health CareHuman ResourcesMarketplaceRecruiting
Series EJun 17, 2024
Amount Raised: $22,000,000
Indico Data

Boston, Massachusetts, United States

Indico Data provides data intelligent intake solutions that automates and enhances data processing tasks.

AnalyticsArtificial Intelligence (AI)Machine LearningSoftware
Series UnknownJun 6, 2024
Amount Raised: $19,000,000
OncoveryCare

Somerville, Massachusetts, United States

OncoveryCare is the virtual survivorship clinic providing whole-person care and community to survivors of critical illness with cancer.

Health Care
SeedMay 23, 2024
Amount Raised: $4,500,000