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F-Prime Capital

North America, Massachusetts, United States, Cambridge

Description

F-Prime Capital is a prominent global venture capital firm with a distinctive dual focus on healthcare and technology sectors. As an affiliate of Fidelity Investments, the firm benefits from deep financial roots and a long-term investment horizon, allowing it to provide patient capital and strategic support to its portfolio companies. Headquartered in Cambridge, Massachusetts, F-Prime has established itself as a significant player in the venture ecosystem, known for its rigorous due diligence and hands-on approach.

The firm's investment strategy spans various stages, from seed to growth, with a particular emphasis on leading or co-leading early-stage rounds, including Seed, Series A, and Series B financings. Within healthcare, F-Prime targets innovative companies in biotech, medtech, and digital health, seeking to back breakthroughs that can transform patient care. In the technology realm, their interests lie in fintech, enterprise technology, and cybersecurity, identifying disruptive solutions that address critical business needs. Their global footprint allows them to source opportunities and support companies across different geographies.

F-Prime Capital is well-capitalized, having recently closed substantial funds to fuel its investment activities. In 2021, the firm announced the closing of a $500 million healthcare fund, followed by a $500 million technology fund in 2022, demonstrating significant capital deployment capacity. For typical first checks, F-Prime's initial investments generally range from approximately $2 million for seed-stage companies to $25 million or more for leading Series A or B rounds, reflecting their commitment to providing meaningful capital to accelerate growth. The firm boasts a strong track record, having invested in over 200 companies, leading to more than 50 IPOs and M&A events, underscoring their success in identifying and nurturing high-potential ventures. This strategic approach, combined with their extensive network and operational expertise, positions F-Prime Capital as a valuable partner for entrepreneurs aiming to build category-defining companies in their specialized domains.

Investor Profile

F-Prime Capital has backed more than 438 startups, with 33 new investments in the last 12 months alone. The firm has led 102 rounds, about 23% of its total and boasts 94 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series A, Series B, Series C rounds (top funding stages).
  • Majority of deals are located in United States, United Kingdom, China.
  • Strong thematic focus on Health Care, Biotechnology, Medical.
  • Led 6 rounds in the past year.
  • Typical check size: $2M – $25M.

Stage Focus

  • Series A (33%)
  • Series B (28%)
  • Series C (13%)
  • Seed (9%)
  • Series Unknown (8%)
  • Series D (5%)
  • Series E (1%)

Country Focus

  • United States (79%)
  • United Kingdom (6%)
  • China (5%)
  • India (3%)
  • Japan (2%)
  • Switzerland (1%)
  • Chile (1%)

Industry Focus

  • Health Care
  • Biotechnology
  • Medical
  • Therapeutics
  • Software
  • Pharmaceutical
  • Medical Device
  • Fintech
  • Financial Services
  • Information Technology
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does F-Prime Capital frequently co-invest with?

OrbiMed
North America, New York, United States, New York
Co-Investments: 21
Google Ventures
North America, California, United States, Mountain View
Co-Investments: 26
New Enterprise Associates
North America, California, United States, Menlo Park
Co-Investments: 18
Y Combinator
North America, California, United States, Mountain View
Co-Investments: 20
.406 Ventures
North America, Massachusetts, United States, Boston
Co-Investments: 16
Polaris Partners
North America, Massachusetts, United States, Boston
Co-Investments: 20
Maverick Ventures
North America, California, United States, San Francisco
Co-Investments: 17
Eight Roads Ventures
Europe, England, United Kingdom, London
Co-Investments: 129
Venrock
North America, California, United States, Palo Alto
Co-Investments: 16
ARCH Venture Partners
North America, Illinois, United States, Chicago
Co-Investments: 33

Which angels does F-Prime Capital often collaborate with?

LW
North America, Washington, United States, Seattle
Shared Deals: 2
PS
North America, Massachusetts, United States, Boston
Shared Deals: 2
RK
North America, New York, United States, New York
Shared Deals: 3
JR
North America, California, United States, San Francisco
Shared Deals: 2
JB
North America, Massachusetts, United States, Boston
Shared Deals: 3
LG
North America, California, United States, San Francisco
Shared Deals: 5
CB
North America, Massachusetts, United States, Boston
Shared Deals: 4
ES
North America, New Jersey, United States, Princeton
Shared Deals: 2
EG
North America, California, United States, San Francisco
Shared Deals: 3
RS
North America, Washington, United States, Seattle
Shared Deals: 2

What are some of recent deals done by F-Prime Capital?

ARTBIO

Cambridge, Massachusetts, United States

ARTBIO is a clinical-stage radiopharmaceutical biotechnology business that is working to create a new class of alpha radioligand medicines.

BiotechnologyHealth CareHospitalMedicalMedical DevicePharmaceutical
Series BJul 29, 2025
Amount Raised: $132,000,000
Avalyn Pharma

Seattle, Washington, United States

Avalyn Pharma is a biopharma company developing therapies for the treatment of idiopathic pulmonary fibrosis and other respiratory diseases.

BiopharmaBiotechnologyMedicalPharmaceutical
Series DJul 22, 2025
Amount Raised: $100,000,000
Ashby

San Francisco, California, United States

Ashby develops human resource software to assist companies with hiring and manpower management.

Human ResourcesManagement Information SystemsRecruitingSoftware
Series DJul 22, 2025
Amount Raised: $50,000,000
Spinwheel

Oakland, California, United States

Transform how your business and your customers see, understand, and act on debt with our industry-leading debt APIs and drop-in modules.

Financial ServicesFinTechMobile PaymentsPaymentsSoftware
Series AJun 23, 2025
Amount Raised: $30,000,000
Canary Technologies

San Francisco, California, United States

Canary Technologies provides a digital guest management platform for hotels streamlining check-in, messaging, payments, and upsells.

Enterprise SoftwareHospitalityHotelProductivity Tools
Series DJun 12, 2025
Amount Raised: $80,000,000
Dataplor

Los Angeles, California, United States

Dataplor is a location intelligence platform that connects businesses with a mobile workforce that is available on demand.

AnalyticsArtificial Intelligence (AI)Big DataInformation TechnologyLocation Based Services
Series BJun 3, 2025
Amount Raised: $20,500,000
Axle Health

Los Angeles, California, United States

Scheduling and workforce management software for home health care providers

Health CareHome Health Care
Series AMay 22, 2025
Amount Raised: $10,000,000
Dinari

Palo Alto, California, United States

Dinari is a fintech company that offers 1:1 backed asset tokens of stocks, ETFs, bonds, REITs, and other assets on the blockchain.

FinanceFinancial ServicesFinTech
Series AMay 1, 2025
Amount Raised: $12,700,000
Toku

Santiago, Region Metropolitana, Chile

Toku is redefining payment collection in LatAm through PRM, helping companies automate revenue and deliver frictionless payment experiences.

B2CFinancial ServicesFinTechInformation TechnologySoftware
Series AApr 17, 2025
Amount Raised: $48,000,000
Galatea Bio

Miami Lakes, Florida, United States

Galatea Bio’s mission is to drive groundbreaking discoveries in healthcare by pairing genetic diversity with cutting-edge data analytics.

Artificial Intelligence (AI)Big DataBiopharmaBiotechnologyHealth CareLife ScienceMachine LearningMedicalPharmaceutical
Series UnknownMar 27, 2025
Amount Raised: $8,000,000