Lewis & Clark Ventures

Lewis & Clark Ventures is a prominent venture capital firm headquartered in St. Louis, Missouri, specializing in early to growth-stage technology companies. The firm strategically targets high-growth opportunities, particularly focusing on B2B software, healthcare IT, and agtech sectors. A key aspect of their investment thesis involves identifying and supporting innovative businesses located in what they consider underserved markets, primarily across the Midwest and other regions often overlooked by coastal VCs. This geographic focus allows them to tap into a rich pipeline of promising startups that may benefit from their capital and operational expertise.

The firm typically leads or co-leads Series A and Series B funding rounds, providing crucial capital for companies transitioning from early product-market fit to scaling operations. Their initial investment checks generally range from $3 million to $7 million, reflecting their commitment to substantial early-stage support. Beyond the initial capital infusion, Lewis & Clark Ventures is known for reserving significant capital for follow-on investments, demonstrating a long-term partnership approach with their portfolio companies as they achieve key milestones and pursue further growth. This strategy ensures continued support through subsequent funding rounds.

Lewis & Clark Ventures has demonstrated a consistent ability to raise and deploy capital, underscoring their established presence in the venture ecosystem. They successfully closed their inaugural fund at $100 million in 2015, followed by a second fund of $125 million in 2019. Their most recent capital raise culminated in Lewis & Clark Ventures III, which closed at $150 million in 2023. This progressive increase in fund size not only signifies investor confidence but also enhances their capacity to support a larger number of companies and make more substantial investments, reinforcing their role as a significant player in the Midwest's tech investment landscape.