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Pillar VC

North America, Massachusetts, United States, Boston

Description

Pillar VC is a Boston-based, seed-stage venture capital firm established in 2016 by Jamie Goldstein, a seasoned venture capitalist who previously founded North Bridge Venture Partners. The firm distinguishes itself with a founder-led approach, aiming to support "unstoppable founders" in building the next generation of impactful companies. Pillar VC primarily focuses on leading seed rounds, providing not only capital but also extensive operational support, connections, coaching, and a unique peer-to-peer network for its portfolio companies.

The firm's investment strategy centers on early-stage companies, with a typical initial check size ranging from $2 million to $5 million. Pillar VC commits to leading these rounds and strategically reserves significant capital for follow-on investments, demonstrating a long-term commitment to its portfolio companies' growth. This approach allows them to be a substantial partner from the very beginning, helping founders navigate the critical early phases of development.

Pillar VC has demonstrated significant capital deployment and fundraising success, having raised a total of $310 million across three distinct funds. Their portfolio spans various sectors, reflecting a broad interest in innovative technologies and business models. The firm's emphasis on a collaborative, founder-centric ecosystem, coupled with its substantial financial backing, positions Pillar VC as a prominent player in the East Coast seed-stage investment landscape, particularly for companies seeking hands-on support beyond just capital.

Investor Profile

Pillar VC has backed more than 129 startups, with 12 new investments in the last 12 months alone. The firm has led 22 rounds, about 17% of its total and boasts 11 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Seed, Series A, Series B rounds (top funding stages).
  • Majority of deals are located in United States, United Kingdom, Israel.
  • Strong thematic focus on Biotechnology, Artificial Intelligence (AI), Software.
  • Typical check size: $2M – $5M.

Stage Focus

  • Seed (57%)
  • Series A (21%)
  • Series B (7%)
  • Series Unknown (6%)
  • Pre Seed (6%)
  • Series D (1%)
  • Private Equity (1%)
  • Series E (1%)
  • Series C (1%)

Country Focus

  • United States (91%)
  • United Kingdom (2%)
  • Israel (2%)
  • Germany (1%)
  • Switzerland (1%)
  • Spain (1%)

Industry Focus

  • Biotechnology
  • Artificial Intelligence (Ai)
  • Software
  • Health Care
  • Information Technology
  • Financial Services
  • Blockchain
  • Fintech
  • Internet
  • Medical
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does Pillar VC frequently co-invest with?

Spark Capital
North America, California, United States, San Francisco
Co-Investments: 5
KdT Ventures
North America, Texas, United States, Austin
Co-Investments: 5
General Catalyst
North America, Massachusetts, United States, Cambridge
Co-Investments: 6
Founder Collective
North America, Massachusetts, United States, Cambridge
Co-Investments: 6
Union Square Ventures
North America, New York, United States, New York
Co-Investments: 4
Lux Capital
North America, New York, United States, New York
Co-Investments: 4
Lowercarbon Capital
North America, Wyoming, United States, Jackson
Co-Investments: 5
Breyer Capital
North America, California, United States, Menlo Park
Co-Investments: 4
Andreessen Horowitz
North America, California, United States, Menlo Park
Co-Investments: 6
Alumni Ventures
North America, New Hampshire, United States, Manchester
Co-Investments: 4

Which angels does Pillar VC often collaborate with?

JM
North America, Massachusetts, United States, Boston
Shared Deals: 1
Balaji Srinivasan
Asia, Central Region, Singapore, Singapore
Shared Deals: 2
SB
North America, California, United States
Shared Deals: 2
WC
North America, New York, United States, Manhattan
Shared Deals: 3
SK
North America, Massachusetts, United States, Boston
Shared Deals: 3
AN
North America, Massachusetts, United States, Cambridge
Shared Deals: 2
JS
North America, California, United States, San Francisco
Shared Deals: 2
JH
North America, United States
Shared Deals: 2
GC
North America, Massachusetts, United States, Boston
Shared Deals: 1
EJ
North America, United States
Shared Deals: 2

What are some of recent deals done by Pillar VC?

Portal Biotech

London, England, United Kingdom

Portal Biotech is a biotechnology company specializing in advanced proteomics and metabolomics through single-molecule detection.

Biotechnology
Series AJun 30, 2025
Amount Raised: $37,073,704
Matterworks

Somerville, Massachusetts, United States

Matterworks is a biotech startup that combines metabolomics with AI to simulate the metabolic environment.

Artificial Intelligence (AI)BiotechnologyMedicalPharmaceutical
Series AJun 3, 2025
Catena Labs

Boston, Massachusetts, United States

Catena Labs incubate independent products spanning identity, communications, AI, and commerce.

Artificial Intelligence (AI)Information TechnologyInternet
SeedMay 20, 2025
Amount Raised: $18,000,000
Lamin

Munich, Bayern, Germany

Open data platform for biology.

Artificial Intelligence (AI)BiotechnologyData IntegrationData ManagementData StorageSoftware Engineering
SeedMay 10, 2025
LightSource

San Francisco, California, United States

LightSource develops a supply chain management platform to help professionals collaborate with their suppliers.

Artificial Intelligence (AI)SaaSSupply Chain Management
Series AMar 31, 2025
Amount Raised: $33,000,000
Latent Labs

London, England, United Kingdom

We are making biology programmable to transform health and sustainability for the benefit of all.

Artificial Intelligence (AI)BiotechnologyGenerative AILife SciencePharmaceutical
Series AFeb 13, 2025
Amount Raised: $40,000,000
VideaHealth

Boston, Massachusetts, United States

VideaHealth is offers dentistAI’s software automatically detects pathologies in dental imaging, helping dentists avoid missing diseases.

BiotechnologyHealth CareSoftware
Series BJan 28, 2025
Amount Raised: $40,000,000
Addis Energy

Somerville, Massachusetts, United States

Addis Energy is on a mission to alter the way we feed and fuel our society, harnessing the Earth's potential for clean ammonia production.

ChemicalManufacturingOil and Gas
Pre SeedJan 21, 2025
Amount Raised: $4,250,000

Cimulate is a generative AI technology company revolutionizing commerce by optimizing the customer journey.

Artificial Intelligence (AI)E-CommerceE-Commerce PlatformsRetail Technology
Series ADec 18, 2024
Amount Raised: $28,000,000

Rowan is a molecular design and simulation tool used by scientists for modeling and analyzing molecular structures and behavior.

BiotechnologyChemicalEnergyPharmaceutical
Pre SeedDec 9, 2024
Amount Raised: $2,100,000